{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:22:30Z","timestamp":1790965350646,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autoimmune disease in Fas-deficient MRL-Faslpr mice is dependent on infiltrating autoreactive leukocytes and autoantibodies, and IFN-\u03b3 plays an important role in the pathogenesis. As IL-18 is capable of inducing IFN-\u03b3 production in T cells, we hypothesized that signaling through IL-18R is involved in the pathogenesis. To investigate the impact of IL-18 in this autoimmune disease, we generated an MRL-Faslpr strain deficient in IL-18R\u03b1. Compared with the wild-type strain, IL-18R\u03b1-deficient MRL-Faslpr mice survived longer and showed a significant reduction in renal pathology, including glomerular IgG deposits, proteinuria, and serum anti-DNA Abs. Intrarenal transcripts encoding IFN-\u03b3, TNF-\u03b1, IL-12, and IL-10, which have been linked to nephritis, were all markedly reduced. Skin lesions, lymphadenopathy, and lung pathology characteristic of the MRL-Faslpr mouse disease were diminished in IL-18R\u03b1-deficient MRL-Faslpr mice. Thus, we conclude that IL-18R\u03b1 signaling is critical to the pathogenesis of autoimmune disease in MRL-Faslpr mice.<\/jats:p>","DOI":"10.4049\/jimmunol.173.8.5312","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:29:16Z","timestamp":1398032956000},"page":"5312-5318","source":"Crossref","is-referenced-by-count":58,"title":["Blockade of IL-18 Receptor Signaling Delays the Onset of Autoimmune Disease in MRL-\n                    <i>Fas<\/i>\n                    <i>lpr<\/i>\n                    Mice"],"prefix":"10.1093","volume":"173","author":[{"given":"Koji","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Funauchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Kanamaru","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology and Rheumatology, Kinki University School of Medicine , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,10,15]]},"reference":[{"key":"2026020214111927100_R1","first-page":"179","volume-title":"Immunol. 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