{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:10:55Z","timestamp":1791443455558,"version":"4.3.3"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although previous studies have investigated the role of IL-27\/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27\/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1\u2212\/\u2212 mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27\/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites.<\/jats:p>","DOI":"10.4049\/jimmunol.173.9.5626","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:56:18Z","timestamp":1398041778000},"page":"5626-5634","source":"Crossref","is-referenced-by-count":194,"title":["The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity"],"prefix":"10.1093","volume":"173","author":[{"given":"David","family":"Artis","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Villarino","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 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Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Inflammation Research, Amgen , Thousand Oaks, CA 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamin","family":"Summer","sequence":"additional","affiliation":[{"name":"Department of Inflammation Research, Amgen , Thousand Oaks, CA 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M","family":"Covey","sequence":"additional","affiliation":[{"name":"Department of Inflammation Research, Amgen , Thousand Oaks, CA 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University , Maidashi, Higashi-ku, Fukuoka ,","place":["Japan"]},{"name":"PRESTO, Japan Science and Technology Agency , Honcho Kawaguchi, Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Koretzky","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 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