{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:21:47Z","timestamp":1791116507419,"version":"4.1.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IFN-\u03b3 plays a critical role in the CD8+ T cell response to infection, but when and if this cytokine directly signals CD8+ T cells during an immune response is unknown. We show that naive Ag-specific CD8+ T cells receive IFN-\u03b3 signals within 12 h after in vivo infection with Listeria monocytogenes and then become unresponsive to IFN-\u03b3 throughout the ensuing Ag-driven expansion phase. Ag-specific CD8+ T cells regain partial IFN-\u03b3 responsiveness throughout the contraction phase, whereas the memory pool exhibits uniform, but reduced, responsiveness that is also modulated during the secondary response. The responsiveness of Ag-specific CD8+ T cells to IFN-\u03b3 correlated with modulation in the expression of IFN-\u03b3R2, but not with IFN-\u03b3R1 or suppressor of cytokine signaling-1. This dynamic regulation suggests that early IFN-\u03b3 signals participate in regulation of the primary CD8+ T cell response program, but that evading or minimizing IFN-\u03b3 signals during expansion and the memory phase may contribute to appropriate regulation of the CD8+ T cell response.<\/jats:p>","DOI":"10.4049\/jimmunol.174.11.6791","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T05:21:28Z","timestamp":1398144088000},"page":"6791-6802","source":"Crossref","is-referenced-by-count":77,"title":["Dynamic Regulation of IFN-\u03b3 Signaling in Antigen-Specific CD8+ T Cells Responding to Infection"],"prefix":"10.1093","volume":"174","author":[{"given":"Jodie S","family":"Haring","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail A","family":"Corbin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Harty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"},{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"2025032706475480100_R1","first-page":"1739","volume-title":"Science","year":"1993"},{"key":"2025032706475480100_R2","first-page":"1742","volume-title":"Science","year":"1993"},{"key":"2025032706475480100_R3","first-page":"1435","volume-title":"J. 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