{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:09:17Z","timestamp":1792652957399,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ex vivo treatment of bone marrow-derived dendritic cells (DCs) with TNF-\u03b1 has been previously shown to induce partial maturation of DCs that are able to suppress autoimmunity. In this study, we demonstrate that i.v. administration of TNF-\u03b1-treated, semimature DCs pulsed with thyrogloblin (Tg), but not with OVA Ag, inhibits the subsequent development of Tg-induced experimental autoimmune thyroiditis (EAT) in CBA\/J mice. This protocol activates CD4+CD25+ T cells in vivo, which secrete IL-10 upon specific recognition of Tg in vitro and express regulatory T cell (Treg)-associated markers such as glucocorticoid-induced TNFR, CTLA-4, and Foxp3. These CD4+CD25+ Treg cells suppressed the proliferation and cytokine release of Tg-specific, CD4+CD25\u2212 effector cells in vitro, in an IL-10-independent, cell contact-dependent manner. Prior adoptive transfer of the same CD4+CD25+ Treg cells into CBA\/J hosts suppressed Tg-induced EAT. These results demonstrate that the tolerogenic potential of Tg-pulsed, semimature DCs in EAT is likely to be mediated through the selective activation of Tg-specific CD4+CD25+ Treg cells and provide new insights for the study of Ag-specific immunoregulation of autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.174.11.7433","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T05:21:28Z","timestamp":1398144088000},"page":"7433-7439","source":"Crossref","is-referenced-by-count":144,"title":["Tolerogenic Semimature Dendritic Cells Suppress Experimental Autoimmune Thyroiditis by Activation of Thyroglobulin-Specific CD4+CD25+ T Cells"],"prefix":"10.1093","volume":"174","author":[{"given":"Panayotis","family":"Verginis","sequence":"first","affiliation":[{"name":"Divisions of Endocrinology and Basic Sciences, Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, NL ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan S","family":"Li","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Basic Sciences, Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, NL ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Carayanniotis","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Basic Sciences, Faculty of Medicine, Memorial University of Newfoundland , St. John\u2019s, NL ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"2025032706482207800_R1","first-page":"245","volume-title":"Nature","year":"1998"},{"key":"2025032706482207800_R2","first-page":"394","volume-title":"Trends Immunol.","year":"2001"},{"key":"2025032706482207800_R3","first-page":"685","volume-title":"Annu. 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