{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:26:49Z","timestamp":1787977609197,"version":"build-2784847793"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Expression of B lymphocyte-induced maturation protein 1 (Blimp-1) transcription factor is essential for promoting B cell differentiation into plasma cells. However, a critical transcription factor for Blimp-1 expression in activated B cells is unclear. When splenic B cells were stimulated with CD40 ligand (CD40L) and IL-4, terminal differentiation was induced in the B cells from c-fos transgenic (H2-c-fos) mice but barely in those from control littermates and from c-fos-deficient mice. AP-1 family and Blimp-1 mRNAs were transiently induced in the control B cells, and overexpression of c-Fos induced a sufficient amount of Blimp-1 for terminal differentiation in the H2-c-fos B cells. When normal and c-fos-deficient B cells were stimulated with LPS, a sufficient amount of Blimp-1 for terminal differentiation was induced in those B cells. However, expression of c-fos\/AP-1 family mRNAs in LPS-stimulated normal B cells was similar to that of normal B cells stimulated with CD40L and IL-4. EMSA and chromatin immunoprecipitation assays using the AP-1-binding DNA sequence in the murine Blimp-1 promoter region demonstrated that AP-1-binding activity in nuclear protein of LPS-stimulated normal B cells was prolonged more than that in normal B cells stimulated with CD40L and IL-4. Furthermore, the percentage of CD138+ B cells within germinal center B cells in the spleen and the number of Ab-forming cells in the bone marrow of H2-c-fos mice was larger than that of control mice 12 days after immunization. Thus, although c-Fos is not essential for Blimp-1 expression, c-Fos\/AP-1 positively regulates Blimp-1 expression and terminal differentiation of activated B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.174.12.7703","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:24:02Z","timestamp":1398018242000},"page":"7703-7710","source":"Crossref","is-referenced-by-count":69,"title":["A Role for c-\n                    <i>fos<\/i>\n                    \/Activator Protein 1 in B Lymphocyte Terminal Differentiation"],"prefix":"10.1093","volume":"174","author":[{"given":"Yusuke","family":"Ohkubo","sequence":"first","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]},{"name":"Department of Medicine and Clinical Oncology (K1), Graduate School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eggi","family":"Arguni","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Okada","sequence":"additional","affiliation":[{"name":"Division of Hematopoiesis, Center for AIDS Research, Kumamoto University , Kumamoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaki","family":"Asari","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyang","family":"O-Wang","sequence":"additional","affiliation":[{"name":"Laboratory for B Lymphocyte Function, Research Center for Allergy and Immunology, RIKEN Yokohama Institute , Yokohama, Kanagawa 230-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ebara","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Oncology (K1), Graduate School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Saisho","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Oncology (K1), Graduate School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tokuhisa","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics (H2), Chiba University , Chiba ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"2026020213045281400_R1","first-page":"297","volume-title":"Cell","year":"1994"},{"key":"2026020213045281400_R2","first-page":"596","volume-title":"Science","year":"1997"},{"key":"2026020213045281400_R3","first-page":"61","volume-title":"Cold Spring Harbor Symp. 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