{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:13:50Z","timestamp":1790745230975,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-4 and IL-13 are potent cytokines that drive production of IgE, which is critical to the development of atopic disease. In this study, we directly compared IgE generation and IgE-dependent mast cell effector function in mouse strains lacking IL-4, IL-13, IL-4 + IL-13, or their common receptor component, IL-4R\u03b1. Although serum IgE was undetectable under resting conditions in most animals deficient in one or both cytokines, peritoneal mast cells from mice lacking IL-4 or IL-13 had only partial reductions in surface IgE level. In contrast, peritoneal mast cells from IL-4\/13\u2212\/\u2212 and IL-4R\u03b1\u2212\/\u2212 animals were severely deficient in surface IgE, and showed no detectable degranulation following treatment with anti-IgE in vitro. Surprisingly, however, intradermal challenge with high concentrations of anti-IgE Ab induced an ear-swelling response in these strains, implying some capacity for IgE-mediated effector function in tissue mast cells. Furthermore, upon specific immunization with OVA, both IL-4\/IL-13\u2212\/\u2212 and IL-4R\u03b1\u2212\/\u2212 mice produced detectable levels of serum IgE and Ag-specific IgG1, and generated strong ear-swelling responses to intradermal administration of anti-IgE. These findings suggest that a mechanism for IgE production exists in vivo that is independent of IL-4 or IL-13.<\/jats:p>","DOI":"10.4049\/jimmunol.174.12.7716","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:24:02Z","timestamp":1398018242000},"page":"7716-7724","source":"Crossref","is-referenced-by-count":92,"title":["IgE Generation and Mast Cell Effector Function in Mice Deficient in IL-4 and IL-13"],"prefix":"10.1093","volume":"174","author":[{"given":"Susan C","family":"Fish","sequence":"first","affiliation":[{"name":"Wyeth Research , Cambridge, MA 02140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra D","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Wyeth Research , Cambridge, MA 02140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J","family":"Goldman","sequence":"additional","affiliation":[{"name":"Wyeth Research , Cambridge, MA 02140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara M M","family":"Williams","sequence":"additional","affiliation":[{"name":"Wyeth Research , Cambridge, MA 02140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion T","family":"Kasaian","sequence":"additional","affiliation":[{"name":"Wyeth Research , Cambridge, MA 02140"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"2026020213032081600_R1","first-page":"22","volume-title":"Curr. 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