{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:48:18Z","timestamp":1789444098694,"version":"build-2803163510"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The protective efficacy of mAbs to Cryptococcus neoformans glucuronoxylomannan depends on Ab isotype. Previous studies in A\/JCr and C57BL\/6J mice showed relative protective efficacy of IgG1, IgG2a \u226b IgG3. However, we now report that in C57BL\/6J \u00d7 129\/Sv mice, IgG3 is protective while IgG1 is not protective, with neither isotype being protective in 129\/Sv mice. IgG1, IgG2a, and IgG3 had different effects on IFN-\u03b3 expression in infected C57BL\/6J \u00d7 129\/Sv mice. IgG1-treated C57BL\/6J \u00d7 129\/Sv mice had significantly more pulmonary eosinophilia than IgG2a- and IgG3-treated C57BL\/6J \u00d7 129\/Sv mice. C. neoformans infection and Ab administration had different effects on Fc\u03b3RI, Fc\u03b3RII, and Fc\u03b3RIII expression in C57BL\/6J, 129\/Sv, and C57BL\/6J \u00d7 129\/Sv mice. Our results indicate that the relative efficacy of Ab isotype function against C. neoformans is a function of the genetic background of the host and that IgG3-mediated protection in C57BL\/6J \u00d7 129\/Sv mice was associated with lower levels of IFN-\u03b3 and fewer pulmonary eosinophils. The dependence of isotype efficacy on host genetics underscores a previously unsuspected complex relationship between the cellular and humoral arms of the adaptive immune response.<\/jats:p>","DOI":"10.4049\/jimmunol.174.12.8017","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:24:02Z","timestamp":1398018242000},"page":"8017-8026","source":"Crossref","is-referenced-by-count":45,"title":["Mouse Genetic Background Is a Major Determinant of Isotype-Related Differences for Antibody-Mediated Protective Efficacy against\n                    <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1093","volume":"174","author":[{"given":"Johanna","family":"Rivera","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"},{"name":"Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"2026020213041100900_R1","first-page":"4225","volume-title":"Infect. 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