{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:06:54Z","timestamp":1770098814979,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although T cells infiltrate many types of murine and human neoplasms, in many instances tumor-specific cytotoxicity is not observed. Strategies to stimulate CTL-mediated antitumor immunity have included in vitro stimulation and\/or genetic engineering of T cells, followed by adoptive transfer into tumor-bearing hosts. In this model of B cell lymphoma in SJL\/J mice, we used Tim-3+ T-bet+ Th1 cells to facilitate the development of tumor-specific CTL. Tumor-specific Th1 cell lines were polarized with IL-12 during in vitro stimulation and long term maintenance. As few as 5 million Tim-3+ T-bet+ Th1 cells enabled recipients to resist growth of malignant transplantable cells. In addition, similar numbers of Th1 cells injected into 2- to 3-mo-old mice inhibited development of the spontaneous primary lymphomas, which normally arise in 90% of aging mice. CFSE+ Th1 cells colocalized with injected tumor cells in vivo and formed conjugates with the tumor cells within follicles, whereas in nontumor-challenged recipients the CFSE+ Th1 cells localized only within the T cell zones of the spleen. These results provide evidence that adoptive immunotherapy with Tim-3+ T-bet+ tumor-specific Th1 cells can be used to induce host cytotoxic responses that inhibit the development and growth of neoplastic cells.<\/jats:p>","DOI":"10.4049\/jimmunol.174.3.1405","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:29:10Z","timestamp":1398032950000},"page":"1405-1415","source":"Crossref","is-referenced-by-count":22,"title":["Tim-3+ T-bet+ Tumor-Specific Th1 Cells Colocalize with and Inhibit Development and Growth of Murine Neoplasms"],"prefix":"10.1093","volume":"174","author":[{"given":"William J","family":"Simmons","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School and Graduate School Biomedical Sciences , Newark, NJ 07101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mythili","family":"Koneru","sequence":"additional","affiliation":[{"name":"Cell Biology, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani","family":"Mohindru","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Northwestern University School of Medicine , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Departments of Pathology, New York University School of Medicine , New York, NY 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Cutro","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School and Graduate School Biomedical Sciences , Newark, NJ 07101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School and Graduate School Biomedical Sciences , Newark, NJ 07101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie H","family":"DeKruyff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine , Palo Alto, CA 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Inghirami","sequence":"additional","affiliation":[{"name":"Departments of Pathology, New York University School of Medicine , New York, NY 10016"},{"name":"Department of Pathology Center for Experimental Research and Medical Studies , Turino ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J","family":"Coyle","sequence":"additional","affiliation":[{"name":"Millennium Pharmaceuticals , Cambridge, MA 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung S","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Immunology, Northwestern University School of Medicine , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M","family":"Ponzio","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School and Graduate School Biomedical Sciences , Newark, NJ 07101"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"2026020212225722800_R1","first-page":"269","volume-title":"Nat. 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