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By overexpressing Delta-1 and Delta-4 ligands in the hemopoietic cells of athymic nu\/nu host mice, we demonstrate that, in vivo and in the absence of a thymus, Delta-1 or Delta-4 expression is sufficient to promote T cell development from the most immature progenitor stages to complete maturation of both CD8+ and CD4+ \u03b1\u03b2 T cells. The mature T cells developing in a Delta-1- or Delta-4-enriched environment express a diverse TCR repertoire, are able to proliferate upon in vitro TCR stimulation, but show different profiles of cytokine production after in vitro anti-CD3 stimulation.<\/jats:p>","DOI":"10.4049\/jimmunol.174.5.2730","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:48:17Z","timestamp":1398023297000},"page":"2730-2737","source":"Crossref","is-referenced-by-count":36,"title":["In Vivo and in Absence of a Thymus, the Enforced Expression of the Notch Ligands Delta-1 or Delta-4 Promotes T Cell Development with Specific Unique Effects"],"prefix":"10.1093","volume":"174","author":[{"given":"Alix","family":"de La Coste","sequence":"first","affiliation":[{"name":"Unite\u0301 de Biologie des Populations Lymphocytaires, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Six","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie Mole\u0301culaire de l\u2019Expression Ge\u0301nique, Centre National de la Recherche Scientifique, Unite\u0301 de Recherche Associe\u0301e 2582, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fazilleau","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Recherche et d\u2019Expertise Immunite\u0301 Anti-Virale, Biothe\u0301rapie et Vaccins, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mascarell","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie des Re\u0301gulations Immunitaires, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Legrand","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie des Populations Lymphocytaires, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Mailhe\u0301","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie des Populations Lymphocytaires, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cumano","sequence":"additional","affiliation":[{"name":"Unite\u0301 de De\u0301veloppement des Lymphocytes, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacine","family":"Laa\u0302bi","sequence":"additional","affiliation":[{"name":"Unite\u0301 de De\u0301veloppement des Lymphocytes, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio A","family":"Freitas","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie des Populations Lymphocytaires, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"key":"2026020214094869100_R1","first-page":"687","volume-title":"Cell","year":"1991"},{"key":"2026020214094869100_R2","first-page":"833","volume-title":"Cell","year":"1997"},{"key":"2026020214094869100_R3","first-page":"547","volume-title":"Immunity","year":"1999"},{"key":"2026020214094869100_R4","first-page":"299","volume-title":"Immunity","year":"1999"},{"key":"2026020214094869100_R5","first-page":"69","volume-title":"Semin. 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