{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:14:49Z","timestamp":1773278089958,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We recently described a novel H2E class II-transgenic model (A\u2212E+) of experimental autoimmune thyroiditis (EAT) that permits disease induction with heterologous thyroglobulin (Tg), but unlike conventional susceptible strains, precludes self-reactivity to autologous mouse Tg. In transgenic E+B10 (A+E+) mice, the presence of endogenous H2A genes is protective against H2E-mediated thyroiditis, inhibiting EAT development. The suppressive effect of H2A genes on H2E-mediated thyroiditis mirrors previous reports of H2E suppression on H2A-mediated autoimmune diseases, including EAT. The mechanism of the reciprocal-suppressive effect between class II genes is unclear, although the involvement of regulatory T cells has been proposed. We have recently reported that CD4+CD25+ regulatory T cells mediate peripheral tolerance induced with mouse Tg in CBA mice. To determine whether these cells play a role in our E+-transgenic model, we first confirmed the existence of CD4+CD25+ T cells regulating thyroiditis in E+B10.Ab0 (A\u2212E+) and B10 (A+E\u2212) mice by i.v. administration of CD25 mAb before EAT induction. The depletion of CD4+CD25+ T cells enhanced thyroiditis induction in the context of either H2E or H2A. Moreover, reconstitution of CD4+CD25+ T cells from naive B10 mice restored resistance to EAT. E+B10 (A+E+) mice were also depleted of CD4+CD25+ T cells before the challenge to determine their role in thyroiditis in the presence of both H2A and H2E genes. Depletion of CD4+CD25+ regulatory T cells offset the suppression of H2E-mediated thyroiditis by H2A. Thus, these regulatory T cells may be involved in the reciprocal-suppressive effect between class II genes.<\/jats:p>","DOI":"10.4049\/jimmunol.174.5.3111","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:48:17Z","timestamp":1398023297000},"page":"3111-3116","source":"Crossref","is-referenced-by-count":22,"title":["H2A- and H2E-Derived CD4+CD25+ Regulatory T Cells: A Potential Role in Reciprocal Inhibition by Class II Genes in Autoimmune Thyroiditis"],"prefix":"10.1093","volume":"174","author":[{"given":"Gerald P","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI, 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI, 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chella S","family":"David","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic , Rochester, MN 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-chi M","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine , Detroit, MI, 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"key":"2026020214102280600_R1","first-page":"146","volume-title":"Eur. 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