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It is accepted that dendritic cells (DC) are efficient in activating naive T cells and are unique in their capacity to prime CD8+ T cell responses against exogenous cell-associated Ags. Nevertheless, it is unclear whether epitopes, derived from endogenously synthesized proteins and presented by MHC class I molecules on the surface of other APC including B cells and macrophages, can activate naive CD8+ T cells in vivo. By infecting transgenic CD11c-DTR\/GFP mice that allow conditional depletion of DC with lymphocytic choriomeningitis virus (LCMV), which infects all types of APC and elicits a vigorous CTL response, we unambiguously show that priming of LCMV-specific CD8+ T cells is crucially dependent on DC, despite ample presence of LCMV-infected macrophages and B cells in secondary lymphoid organs.<\/jats:p>","DOI":"10.4049\/jimmunol.174.7.3920","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T02:39:15Z","timestamp":1398220755000},"page":"3920-3924","source":"Crossref","is-referenced-by-count":111,"title":["Priming of CTLs by Lymphocytic Choriomeningitis Virus Depends on Dendritic Cells"],"prefix":"10.1093","volume":"174","author":[{"given":"Hans Christian","family":"Probst","sequence":"first","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maries","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University Hospital Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,4,1]]},"reference":[{"key":"2025032706330912200_R1","first-page":"211","volume-title":"Immunity","year":"2002"},{"key":"2025032706330912200_R2","first-page":"1627","volume-title":"J. 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