{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:26:06Z","timestamp":1770096366943,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Marginal zone (MZ) B cells and peritoneal B-1 cells provide a first defense system of thymus-independent Ab responses against foreign pathogens and therefore share a number of functional properties. Recently, development of B-1a cells was shown to be controlled by the transcription factor NFATc1. We show here that mice deficient for NFATc2 and c3 display a distinct lower representation of MZ B cells, which is correlated with a reduced capturing of trinitrophenyl-Ficoll. In contrast, mature follicular B cells from NFATc2\/c3\u2212\/\u2212 mice are strongly increased in number. NFATc2\/c3\u2212\/\u2212 B cells exhibit a marked increase in BCR-induced intracellular Ca2+ mobilization and proliferation. However, trinitrophenyl-Ficoll-specific IgM and IgG3 responses of NFATc2\/c3-deficient mice are intact, and chimeric mice reconstituted with NFATc2\/3-deficient B cells show a normal number of MZ B cells and normal BCR responses. These observations suggest that the strongly elevated Th2 cytokine milieu in NFATc2\/c3-deficient mice leads to a hyperactivation of mature, follicular B cells, whereas MZ B cells are less responsive to these signals.<\/jats:p>","DOI":"10.4049\/jimmunol.174.8.4797","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:25:14Z","timestamp":1398032714000},"page":"4797-4802","source":"Crossref","is-referenced-by-count":14,"title":["B Cell Hyperresponsiveness and Expansion of Mature Follicular B Cells but Not of Marginal Zone B Cells in NFATc2\/c3 Double-Deficient Mice"],"prefix":"10.1093","volume":"174","author":[{"given":"Devapriya Nandini","family":"Samanta","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology, Institute of Pathology , Wu\u0308rzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alois","family":"Palmetshofer","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Institute of Pathology , Wu\u0308rzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, University of Ulm , Ulm ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wirth","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, University of Ulm , Ulm ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Serfling","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Institute of Pathology , Wu\u0308rzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Nitschke","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology, University of Wu\u0308rzburg , Wu\u0308rzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,4,15]]},"reference":[{"key":"2026020213030419500_R1","first-page":"1","volume-title":"Biochim. Biophys. Acta","year":"2000"},{"key":"2026020213030419500_R2","first-page":"2205","volume-title":"Genes Dev.","year":"2003"},{"key":"2026020213030419500_R3","first-page":"S67","volume-title":"Cell","year":"2002"},{"key":"2026020213030419500_R4","first-page":"61","volume-title":"Nucleic Acids Res.","year":"1991"},{"key":"2026020213030419500_R5","first-page":"277","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020213030419500_R6","first-page":"131","volume-title":"Curr. Top. Microbiol. Immunol.","year":"2000"},{"key":"2026020213030419500_R7","first-page":"7519","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020213030419500_R8","first-page":"13459","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026020213030419500_R9","first-page":"9","volume-title":"Immunol. Rev.","year":"2000"},{"key":"2026020213030419500_R10","first-page":"771","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020213030419500_R11","first-page":"253","volume-title":"Annu. Rev. Immunol.","year":"2002"},{"key":"2026020213030419500_R12","first-page":"323","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020213030419500_R13","first-page":"195","volume-title":"Curr. Opin. Immunol.","year":"2001"},{"key":"2026020213030419500_R14","first-page":"945","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020213030419500_R15","first-page":"603","volume-title":"Immunity","year":"2001"},{"key":"2026020213030419500_R16","first-page":"561","volume-title":"Eur. J. Immunol.","year":"2002"},{"key":"2026020213030419500_R17","first-page":"409","volume-title":"Science","year":"2002"},{"key":"2026020213030419500_R18","first-page":"627","volume-title":"Immunity","year":"1998"},{"key":"2026020213030419500_R19","first-page":"1207","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020213030419500_R20","first-page":"3418","volume-title":"Eur. J. Immunol.","year":"2003"},{"key":"2026020213030419500_R21","first-page":"423","volume-title":"Nature","year":"1991"},{"key":"2026020213030419500_R22","first-page":"6065","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1992"},{"key":"2026020213030419500_R23","first-page":"75","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020213030419500_R24","first-page":"1175","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020213030419500_R25","first-page":"31","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2026020213030419500_R26","first-page":"317","volume-title":"Nat. Immunol.","year":"2004"},{"key":"2026020213030419500_R27","first-page":"7198","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213030419500_R28","first-page":"333","volume-title":"J. Exp. Med.","year":"2003"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/174\/8\/4797\/62615419\/4797.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/174\/8\/4797\/62615419\/4797.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:03:45Z","timestamp":1770055425000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/174\/8\/4797\/8037101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2005,4,15]]},"published-print":{"date-parts":[[2005,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.174.8.4797","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,4]]},"published":{"date-parts":[[2005,4]]}}}