{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:32:04Z","timestamp":1773675124257,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Secreted IgA plays a pivotal role in the mucosal immunity to maintain the front line of body defense. We found that the level of fecal IgA was dramatically decreased in aged (NZB \u00d7 NZW)F1 (BWF1) mice developing lupus nephritis, whereas levels in similarly aged New Zealand Black (NZB) and New Zealand White (NZW) mice remained unchanged compared with young mice. The number of cells obtained from Peyer\u2019s patches was markedly decreased in aged BWF1 mice. Aged BWF1 mice showed increased susceptibility to pathogenic bacterial infection. Furthermore, oral administration of OVA failed to inhibit secondary IgG response induced by systemic immunization, suggesting defective oral tolerance in aged BWF1 mice. A significant amount of orally administered OVA was incorporated directly into the intestinal lamina propria in aged BWF1 mice whereas it was mainly localized in subepithelial domes and interfollicular region in Peyer\u2019s patches in young mice. T cells obtained from renal and pulmonary lymph nodes of aged BWF1 mice that had been orally administered with OVA showed an Ag-specific T cell proliferation, whereas those from young BWF1, aged NZB, and aged NZW mice did not. Interestingly, aerosol exposure to OVA of aged BWF1 mice, which had been orally administered with the same Ag, provoked an eosinophil infiltration in the lung. These results demonstrate that mucosal immunity in the gut is impaired and oral Ags induce systemic sensitization instead of oral tolerance in the development of murine lupus.<\/jats:p>","DOI":"10.4049\/jimmunol.174.9.5499","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:51:00Z","timestamp":1398127860000},"page":"5499-5506","source":"Crossref","is-referenced-by-count":14,"title":["Breakdown of Mucosal Immunity in the Gut and Resultant Systemic Sensitization by Oral Antigens in a Murine Model for Systemic Lupus Erythematosus"],"prefix":"10.1093","volume":"174","author":[{"given":"Kenji","family":"Akadegawa","sequence":"first","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]},{"name":"Department of Respirology, Graduate School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Yurino","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kitabatake","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine, Chiba University , Chiba ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"2026020213051069100_R1","first-page":"133","volume-title":"Mucosal Immunology","year":"1999"},{"key":"2026020213051069100_R2","first-page":"188","volume-title":"J. 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