{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:17:54Z","timestamp":1790839074415,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In addition to their well known immune and proinflammatory activities, IFNs possess homeostatic functions that limit inflammation and tissue destruction in a variety of conditions such as arthritis, osteolysis, and multiple sclerosis. The mechanisms underlying the homeostatic actions of IFNs are not well understood. We report here that both type I and type II IFNs (IFN-\u03b1, IFN-\u03b2, and IFN-\u03b3, respectively) suppressed a broad range of proinflammatory and tissue-destructive activities of IL-1, including induction of inflammatory mediators, production of matrix metalloproteinases, macrophage tissue invasion, and cartilage degradation. IFN-\u03b1 attenuated IL-1-mediated cell recruitment in vivo. IFNs completely suppressed the activation of IL-1 signal transduction pathways in macrophages. The mechanism of IFN-mediated inhibition of IL-1 action and signaling was modulation of IL-1R expression, which was also observed in vivo. IFN-\u03b3-mediated down-regulation of IL-1R type I expression was dependent on Stat1, a transcription factor typically considered to be a key mediator of macrophage activation by IFNs. These results identify cellular and molecular mechanisms that contribute to the homeostatic role of IFNs in limiting inflammation and associated tissue destruction.<\/jats:p>","DOI":"10.4049\/jimmunol.175.1.131","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:08:21Z","timestamp":1398042501000},"page":"131-138","source":"Crossref","is-referenced-by-count":45,"title":["Homeostatic Role of Interferons Conferred by Inhibition of IL-1-Mediated Inflammation and Tissue Destruction"],"prefix":"10.1093","volume":"175","author":[{"given":"Xiaoyu","family":"Hu","sequence":"first","affiliation":[{"name":"Arthritis and Tissue Degeneration Program, Weill Graduate School of Medical Sciences of Cornell University New York , NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao H","family":"Ho","sequence":"additional","affiliation":[{"name":"Arthritis and Tissue Degeneration Program, Weill Graduate School of Medical Sciences of Cornell University New York , NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Lou","sequence":"additional","affiliation":[{"name":"Graduate Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University New York , NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisa","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Musculoskeletal Integrity Program, Department of Medicine, Hospital for Special Surgery, Weill Graduate School of Medical Sciences of Cornell University New York , NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel B","family":"Ivashkiv","sequence":"additional","affiliation":[{"name":"Arthritis and Tissue Degeneration Program, Weill Graduate School of Medical Sciences of Cornell University New York , NY 10021"},{"name":"Graduate Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University New York , NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"2025032808272243500_R1","first-page":"227","volume-title":"Annu. Rev. Biochem.","year":"1998"},{"key":"2025032808272243500_R2","first-page":"63","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2025032808272243500_R3","first-page":"69","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2025032808272243500_R4","first-page":"163","volume-title":"J. Leukocyte Biol.","year":"2004"},{"key":"2025032808272243500_R5","first-page":"5501","volume-title":"J. Immunol.","year":"1997"},{"key":"2025032808272243500_R6","first-page":"5507","volume-title":"J. Immunol.","year":"1997"},{"key":"2025032808272243500_R7","first-page":"2413","volume-title":"Arthritis Rheum.","year":"2001"},{"key":"2025032808272243500_R8","first-page":"1641","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2025032808272243500_R9","first-page":"3223","volume-title":"J. Immunol.","year":"1996"},{"key":"2025032808272243500_R10","first-page":"685","volume-title":"Neuron","year":"2003"},{"key":"2025032808272243500_R11","first-page":"744","volume-title":"Nature","year":"2002"},{"key":"2025032808272243500_R12","first-page":"220","volume-title":"Rev. Immunogenet.","year":"2000"},{"key":"2025032808272243500_R13","first-page":"6674","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2025032808272243500_R14","first-page":"6680","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2025032808272243500_R15","first-page":"4220","volume-title":"J. Immunol.","year":"2000"},{"key":"2025032808272243500_R16","first-page":"25","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2025032808272243500_R17","first-page":"2014","volume-title":"Arthritis Rheum.","year":"2004"},{"key":"2025032808272243500_R18","first-page":"1979","volume-title":"Genes Dev.","year":"2003"},{"key":"2025032808272243500_R19","first-page":"2095","volume-title":"Blood","year":"1996"},{"key":"2025032808272243500_R20","first-page":"373","volume-title":"Nat. Immunol","year":"2004"},{"key":"2025032808272243500_R21","first-page":"920","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2025032808272243500_R22","first-page":"ii3","volume-title":"Rheumatology (Oxford)","year":"2003"},{"key":"2025032808272243500_R23","first-page":"656","volume-title":"Arterioscler. Thromb. Vasc. Biol.","year":"2003"},{"key":"2025032808272243500_R24","first-page":"319","volume-title":"Immunity","year":"2004"},{"key":"2025032808272243500_R25","first-page":"2196","volume-title":"Arthritis Rheum.","year":"1998"},{"key":"2025032808272243500_R26","first-page":"614","volume-title":"Arthritis Rheum.","year":"2002"},{"key":"2025032808272243500_R27","first-page":"2583","volume-title":"N. Engl. J. Med.","year":"2003"},{"key":"2025032808272243500_R28","first-page":"607","volume-title":"Arthritis Rheum.","year":"2004"},{"key":"2025032808272243500_R29","first-page":"2708","volume-title":"Arthritis Rheum.","year":"2004"},{"key":"2025032808272243500_R30","first-page":"345","volume-title":"Arthritis Rheum.","year":"2004"},{"key":"2025032808272243500_R31","first-page":"ii29","volume-title":"Rheumatology (Oxford)","year":"2003"},{"key":"2025032808272243500_R32","first-page":"859","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2025032808272243500_R33","first-page":"5395","volume-title":"J. Immunol.","year":"2001"},{"key":"2025032808272243500_R34","first-page":"443","volume-title":"Cell.","year":"1996"},{"key":"2025032808272243500_R35","first-page":"431","volume-title":"Cell","year":"1996"},{"key":"2025032808272243500_R36","first-page":"143","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2025032808272243500_R37","first-page":"247","volume-title":"Connect. Tissue Res.","year":"1982"},{"key":"2025032808272243500_R38","first-page":"401","volume-title":"Nat. Genet.","year":"2003"},{"key":"2025032808272243500_R39","first-page":"207","volume-title":"Nat. Rev. Mol. Cell Biol.","year":"2002"},{"key":"2025032808272243500_R40","first-page":"2855","volume-title":"Rheumatology","year":"2003"},{"key":"2025032808272243500_R41","first-page":"1081","volume-title":"J. Clin. Invest.","year":"2001"},{"key":"2025032808272243500_R42","first-page":"1704","volume-title":"Science","year":"2003"},{"key":"2025032808272243500_R43","first-page":"972","volume-title":"Rheumatology (Oxford)","year":"2002"},{"key":"2025032808272243500_R44","first-page":"499","volume-title":"Nat. Rev. Immunol.","year":"2004"},{"key":"2025032808272243500_R45","first-page":"96","volume-title":"Trends Immunol.","year":"2002"},{"key":"2025032808272243500_R46","first-page":"41679","volume-title":"J. Biol. Chem.","year":"2004"},{"key":"2025032808272243500_R47","first-page":"2092","volume-title":"Arthritis Rheum.","year":"2003"},{"key":"2025032808272243500_R48","first-page":"600","volume-title":"Nature","year":"2000"},{"key":"2025032808272243500_R49","first-page":"1504","volume-title":"Science","year":"2000"},{"key":"2025032808272243500_R50","first-page":"1","volume-title":"Rev. Physiol. Biochem. Pharmacol.","year":"2003"},{"key":"2025032808272243500_R51","first-page":"27399","volume-title":"J. Biol. Chem.","year":"2004"},{"key":"2025032808272243500_R52","first-page":"358","volume-title":"Trends Immunol.","year":"2003"},{"key":"2025032808272243500_R53","first-page":"39","volume-title":"Immunity","year":"1999"},{"key":"2025032808272243500_R54","first-page":"2132","volume-title":"Arthritis Rheum.","year":"2003"},{"key":"2025032808272243500_R55","first-page":"1901","volume-title":"Infect. Immun.","year":"1999"},{"key":"2025032808272243500_R56","first-page":"R73","volume-title":"Arthritis Res. Ther.","year":"2004"},{"key":"2025032808272243500_R57","first-page":"1039","volume-title":"Ann. Rheum. Dis.","year":"1992"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/1\/131\/62620878\/131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/1\/131\/62620878\/131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:32:01Z","timestamp":1743381121000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/175\/1\/131\/8035793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.175.1.131","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,7]]},"published":{"date-parts":[[2005,7,1]]}}}