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Whether priming of CTLs by CD8\u03b1+ DCs is limited to cytolytic viruses, which may provide dead cellular material for this DC subset, or whether these DCs selectively present intracellular Ags, is unknown. To address this question, we examined Ag presentation to a noncytolytic virus, lymphocytic choriomeningitis virus, and to an intracellular bacterium, Listeria monocytogenes. We show that regardless of the type of intracellular infection, CD8\u03b1+ DCs are the principal DC subset that initiate CD8+ T cell immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.175.1.196","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:08:21Z","timestamp":1398042501000},"page":"196-200","source":"Crossref","is-referenced-by-count":153,"title":["CD8\u03b1+ Dendritic Cells Selectively Present MHC Class I-Restricted Noncytolytic Viral and Intracellular Bacterial Antigens In Vivo"],"prefix":"10.1093","volume":"175","author":[{"given":"Gabrielle T","family":"Belz","sequence":"first","affiliation":[{"name":"Division of Immunology, Walter and Eliza Hall Institute of Medical Research , Melbourne, Victoria ,","place":["Australia"]},{"name":"Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shortman","sequence":"additional","affiliation":[{"name":"Division of Immunology, Walter and Eliza Hall Institute of Medical Research , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Bevan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Heath","sequence":"additional","affiliation":[{"name":"Division of Immunology, Walter and Eliza Hall Institute of Medical Research , Melbourne, Victoria ,","place":["Australia"]},{"name":"Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"2025032808264152700_R1","first-page":"211","volume-title":"Immunity","year":"2002"},{"key":"2025032808264152700_R2","first-page":"2978","volume-title":"J. 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