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However, most experiments addressing the role of Abs and CD8+ T cells in protection have used viruses that are not specific for the host. In the present study, we used the mouse-specific OPV ectromelia virus and mice deficient in CD40, B cells, or CD8+ T cells and adoptive transfers of CD8+ T or B lymphocytes to show that the protection afforded by CD8+ T cells is incomplete. Despite sustained CD8+ T cell responses, in the absence of Ab responses ectromelia virus persists. This results in delayed disease and inexorably leads to death. Therefore, CD8+ T lymphocytes and Abs are not redundant but complementary and essential to survive infections with a highly pathogenic viruses in the natural host.<\/jats:p>","DOI":"10.4049\/jimmunol.175.10.6829","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:57:58Z","timestamp":1398027478000},"page":"6829-6836","source":"Crossref","is-referenced-by-count":112,"title":["Antibodies and CD8+ T Cells Are Complementary and Essential for Natural Resistance to a Highly Lethal Cytopathic Virus"],"prefix":"10.1093","volume":"175","author":[{"given":"Min","family":"Fang","sequence":"first","affiliation":[{"name":"Fox Chase Cancer Center, Basic Sciences Division, Program on Viral Pathogenesis , Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J","family":"Sigal","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Basic Sciences Division, Program on Viral Pathogenesis , Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,11,15]]},"reference":[{"key":"2026020212191248200_R1","first-page":"275","volume-title":"Annu. 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