{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:10:23Z","timestamp":1770336623852,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic beryllium disease (CBD) is characterized by a CD4+ T cell alveolitis and granulomatous inflammation in the lung. Genetic susceptibility to this disease has been linked with HLA-DP alleles, particularly those possessing a glutamic acid at position 69 (Glu69) of the \u03b2-chain. However, 15% of CBD patients do not possess a Glu69-containing HLA-DP allele, suggesting that other MHC class II alleles may be involved in disease susceptibility. In CBD patients without a Glu69-containing HLA-DP allele, an increased frequency of HLA-DR13 alleles has been described, and these alleles possess a glutamic acid at position 71 of the \u03b2-chain (which corresponds to position 69 of HLA-DP). Thus, we hypothesized that beryllium presentation to CD4+ T cells was dependent on a glutamic acid residue at the identical position of both HLA-DP and -DR. The results show that HLA-DP Glu69- and HLA-DR Glu71-expressing molecules are capable of inducing beryllium-specific proliferation and IFN-\u03b3 expression by lung CD4+ T cells. Using fibroblasts expressing mutated HLA-DP2 and -DR13 molecules, beryllium recognition was dependent on the glutamic acid at position 69 of HLA-DP and 71 of HLA-DR, suggesting a critical role for this amino acid in beryllium presentation to Ag-specific CD4+ T cells. Thus, these results demonstrate that a single amino acid residue of the MHC class II \u03b2-chain dictates beryllium presentation and potentially, disease susceptibility.<\/jats:p>","DOI":"10.4049\/jimmunol.175.10.7029","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:57:58Z","timestamp":1398027478000},"page":"7029-7037","source":"Crossref","is-referenced-by-count":57,"title":["Beryllium Presentation to CD4+ T Cells Is Dependent on a Single Amino Acid Residue of the MHC Class II \u03b2-Chain"],"prefix":"10.1093","volume":"175","author":[{"given":"Jerome R","family":"Bill","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"},{"name":"Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G","family":"Mack","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T","family":"Falta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"},{"name":"Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"},{"name":"Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center , Denver, CO 80262"},{"name":"Department of Medicine, National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew K","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenneke G","family":"Joslin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison K","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M","family":"Freed","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"},{"name":"Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L","family":"Kotzin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"},{"name":"Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P","family":"Fontenot","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Health Sciences Center , Denver, CO 80262"},{"name":"Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,15]]},"reference":[{"key":"2026020212204552700_R1","first-page":"435","volume-title":"Interstitial Lung Disease","year":"2003"},{"key":"2026020212204552700_R2","first-page":"603","volume-title":"J. 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