{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:19:32Z","timestamp":1790630372566,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a\u2212\/\u2212) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a\u2212\/\u2212 mice compared with WT mice. Similarly, Cd59a\u2212\/\u2212 T cells responded more vigorously to in vitro stimulation with CD3-specific Abs compared with WT mice. This effect of CD59a on T cell proliferation was found to be complement-independent. Collectively, these results demonstrate that CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation.<\/jats:p>","DOI":"10.4049\/jimmunol.175.11.7098","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:05:46Z","timestamp":1398042346000},"page":"7098-7102","source":"Crossref","is-referenced-by-count":59,"title":["Cutting Edge: Murine CD59a Modulates Antiviral CD4+ T Cell Activity in a Complement-Independent Manner"],"prefix":"10.1093","volume":"175","author":[{"given":"M Paula","family":"Longhi","sequence":"first","affiliation":[{"name":"Medical Biochemistry and Immunology, School of Medicine, Cardiff University , Wales ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baalasubramanian","family":"Sivasankar","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Immunology, School of Medicine, Cardiff University , Wales ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Omidvar","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Immunology, School of Medicine, Cardiff University , Wales ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Paul","family":"Morgan","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Immunology, School of Medicine, Cardiff University , Wales ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awen","family":"Gallimore","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Immunology, School of Medicine, Cardiff University , Wales ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"2025032706020965800_R1","first-page":"532","volume-title":"Invest.","year":"1991"},{"key":"2025032706020965800_R2","first-page":"537","volume-title":"Physiol.","year":"2002"},{"key":"2025032706020965800_R3","first-page":"4092","volume-title":"J. 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