{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:35:19Z","timestamp":1791200119075,"version":"4.2.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Elicitation of contact sensitivity (CS), a classic example of T cell-mediated immunity, requires Ag-specific IgM Abs to trigger an initiation process. This early process leads to local recruitment of CS-effector T cells after secondary Ag challenge. These Abs are produced by the B-1 subset of B cells within 1 day after primary skin immunization. In this study we report the surprising observation that B-1 cells in the peritoneal cavity are activated as early as 1 h after naive mice are painted with a contact-sensitizing Ag on the skin of the trunk and feet to begin the initiation of CS. B-1 cells in the spleen and draining lymph nodes produce the initiating Abs by 1 day after immunization, when we found increased numbers of Ag-specific IgM Ab-producing cells in these tissues by ELISPOT assay. Importantly, we show that contact-activated peritoneal B-1 cells migrate to these lymphoid tissues and then differentiate into Ag-specific IgM Ab-producing cells, resulting in specific CS-initiating IgM Abs in the serum by 1 day. Furthermore, pertussis toxin, which is known to inhibit signaling via G protein-coupled chemokines, inhibited the migration of contact-activated peritoneal B-1 cells to the lymphoid tissues, probably due to BLR-1 (Burkitt lymphoma receptor-1). These findings indicate that within 1 h after contact skin immunization, B-1 cells in the peritoneal cavity are activated to migrate to the lymphoid tissues by chemokine-dependent mechanisms to produce serum Ag-specific IgM Abs within 1 day after immunization, leading to local recruitment of CS-effector T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.175.11.7170","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:05:46Z","timestamp":1398027946000},"page":"7170-7178","source":"Crossref","is-referenced-by-count":60,"title":["An Hour after Immunization Peritoneal B-1 Cells Are Activated to Migrate to Lymphoid Organs Where within 1 Day They Produce IgM Antibodies That Initiate Elicitation of Contact Sensitivity"],"prefix":"10.1093","volume":"175","author":[{"given":"Atsuko","family":"Itakura","sequence":"first","affiliation":[{"name":"Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Szczepanik","sequence":"additional","affiliation":[{"name":"Department of Human Developmental Biology, Jagiellonian University College of Medicine , Krakow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis A","family":"Campos","sequence":"additional","affiliation":[{"name":"Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Paliwal","sequence":"additional","affiliation":[{"name":"Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Majewska","sequence":"additional","affiliation":[{"name":"Department of Human Developmental Biology, Jagiellonian University College of Medicine , Krakow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Division of Immunology, Institute of Medical Science, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W","family":"Askenase","sequence":"additional","affiliation":[{"name":"Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine , New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"2026020214053319300_R1","first-page":"425","volume-title":"Middleton\u2019s Allergy: Principles and Practice","year":"2003"},{"key":"2026020214053319300_R2","first-page":"421","volume-title":"Lab. 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