{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:39:01Z","timestamp":1791275941701,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MRL\/lpr mice develop spontaneous glomerulonephritis that is essentially identical with diffuse proliferative glomerulonephritis (World Health Organization class IV) in human lupus nephritis. Lupus nephritis is one of the most serious complications of systemic lupus erythematosus. Diffuse proliferative glomerulonephritis is associated with autoimmune responses dominated by Th1 cells producing high levels of IFN-\u03b3. The initial mounting of Th1 responses depends on the function of the WSX-1 gene, which encodes a subunit of the IL-27R with homology to IL-12R. In mice deficient for the WSX-1 gene, proper Th1 differentiation was impaired and abnormal Th2 skewing was observed during infection with some intracellular pathogens. Disruption of the WSX-1 gene dramatically changed the pathophysiology of glomerulonephritis developing in MRL\/lpr mice. WSX-1\u2212\/\u2212 MRL\/lpr mice developed disease resembling human membranous glomerulonephritis (World Health Organization class V) with a predominance of IgG1 in glomerular deposits, accompanied by increased IgG1 and IgE in the sera. T cells in WSX-1\u2212\/\u2212 MRL\/lpr mice displayed significantly reduced IFN-\u03b3 production along with elevated IL-4 expression. Loss of WSX-1 thus favors Th2-type autoimmune responses, suggesting that the Th1\/Th2 balance may be a pivotal determinant of human lupus nephritis development.<\/jats:p>","DOI":"10.4049\/jimmunol.175.11.7185","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:05:46Z","timestamp":1398042346000},"page":"7185-7192","source":"Crossref","is-referenced-by-count":96,"title":["Membranous Glomerulonephritis Development with Th2-Type Immune Deviations in MRL\/<i>lpr<\/i> Mice Deficient for IL-27 Receptor (WSX-1)"],"prefix":"10.1093","volume":"175","author":[{"given":"Sakiko","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naonobu","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohsuke","family":"Masutani","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sadanaga","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Faculty of Medicine, Saga University , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuteru","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]},{"name":"Laboratory for Genetics of Allergic Diseases, Single Nucleotide Polymorphism (SNP) Research Center, RIKEN Yokohama Institute, The Institute of Physical and Chemical Research (RIKEN) , Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Katafuchi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hirakata","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Faculty of Medicine, Saga University , Saga ,","place":["Japan"]},{"name":"Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"2025032706032363800_R1","first-page":"157","volume-title":"Immunol. Rev.","year":"1995"},{"key":"2025032706032363800_R2","first-page":"269","volume-title":"Immunol.","year":"1985"},{"key":"2025032706032363800_R3","first-page":"493","volume-title":"Am. J. Med.","year":"1968"},{"key":"2025032706032363800_R4","volume-title":"Renal Disease: Classification and Atlas of Glomerular Disease","year":"1995"},{"key":"2025032706032363800_R5","first-page":"1644","volume-title":"Arthritis Rheum.","year":"1999"},{"key":"2025032706032363800_R6","first-page":"2097","volume-title":"Arthritis Rheum.","year":"2001"},{"key":"2025032706032363800_R7","first-page":"223","volume-title":"Immunopathol.","year":"1983"},{"key":"2025032706032363800_R8","first-page":"207","volume-title":"Invest.","year":"2000"},{"key":"2025032706032363800_R9","first-page":"1597","volume-title":"Invest.","year":"1996"},{"key":"2025032706032363800_R10","first-page":"494","volume-title":"J. Immunol.","year":"1998"},{"key":"2025032706032363800_R11","first-page":"5484","volume-title":"J. Immunol.","year":"1997"},{"key":"2025032706032363800_R12","first-page":"3915","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032706032363800_R13","first-page":"82","volume-title":"Res. Commun.","year":"1998"},{"key":"2025032706032363800_R14","first-page":"916","volume-title":"Nature","year":"2000"},{"key":"2025032706032363800_R15","first-page":"569","volume-title":"Immunity","year":"2001"},{"key":"2025032706032363800_R16","first-page":"47","volume-title":"Pathol.","year":"1989"},{"key":"2025032706032363800_R17","first-page":"1198","volume-title":"J. Exp. Med.","year":"1978"},{"key":"2025032706032363800_R18","first-page":"228","volume-title":"Physicians","year":"1999"},{"key":"2025032706032363800_R19","first-page":"1105","volume-title":"Kelly\u2019s Textbook of Rheumatology","year":"2001"},{"key":"2025032706032363800_R20","first-page":"779","volume-title":"Immunity","year":"2002"},{"key":"2025032706032363800_R21","first-page":"4886","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032706032363800_R22","first-page":"657","volume-title":"Immunity","year":"2003"},{"key":"2025032706032363800_R23","first-page":"645","volume-title":"Immunity","year":"2003"},{"key":"2025032706032363800_R24","first-page":"4672","volume-title":"J. Immunol.","year":"2004"},{"key":"2025032706032363800_R25","first-page":"377","volume-title":"Kidney Int.","year":"1983"},{"key":"2025032706032363800_R26","volume-title":"Immune Complex Deposit and Anti-Basement Membrane Disease","year":"1973"},{"key":"2025032706032363800_R27","first-page":"358","volume-title":"Am. J. Kidney Dis.","year":"1994"},{"key":"2025032706032363800_R28","first-page":"270","volume-title":"Kidney Int.","year":"1997"},{"key":"2025032706032363800_R29","first-page":"223","volume-title":"Today","year":"1991"},{"key":"2025032706032363800_R30","first-page":"670","volume-title":"Lancet","year":"1998"},{"key":"2025032706032363800_R31","first-page":"1198","volume-title":"Kidney Int.","year":"1999"},{"key":"2025032706032363800_R32","first-page":"580","volume-title":"Transplant.","year":"2004"},{"key":"2025032706032363800_R33","first-page":"460","volume-title":"J. Exp. Med.","year":"1982"},{"key":"2025032706032363800_R34","first-page":"880","volume-title":"J. Immunol.","year":"1985"},{"key":"2025032706032363800_R35","first-page":"565","volume-title":"Immunology","year":"1985"},{"key":"2025032706032363800_R36","first-page":"155","volume-title":"Am. J. Pathol.","year":"1983"},{"key":"2025032706032363800_R37","first-page":"944","volume-title":"Science","year":"1987"},{"key":"2025032706032363800_R38","first-page":"303","volume-title":"Annu. Rev. Immunol.","year":"1990"},{"key":"2025032706032363800_R39","first-page":"229","volume-title":"Immunol.","year":"1993"},{"key":"2025032706032363800_R40","first-page":"502","volume-title":"Invest.","year":"1978"},{"key":"2025032706032363800_R41","first-page":"1275","volume-title":"Invest.","year":"1978"},{"key":"2025032706032363800_R42","first-page":"651","volume-title":"Am. J. Pathol.","year":"1994"},{"key":"2025032706032363800_R43","first-page":"5557","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1982"},{"key":"2025032706032363800_R44","first-page":"4818","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032706032363800_R45","first-page":"33","volume-title":"Rev.","year":"2004"},{"key":"2025032706032363800_R46","first-page":"255","volume-title":"Nephron.","year":"2002"},{"key":"2025032706032363800_R47","first-page":"297","volume-title":"Immunol.","year":"1995"},{"key":"2025032706032363800_R48","first-page":"E3","volume-title":"Am. J. Kidney Dis.","year":"2000"},{"key":"2025032706032363800_R49","first-page":"351","volume-title":"Am. J. Nephrol.","year":"2001"},{"key":"2025032706032363800_R50","first-page":"260","volume-title":"Nephron.","year":"2001"},{"key":"2025032706032363800_R51","first-page":"209","volume-title":"Immunol.","year":"1971"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/11\/7185\/62628872\/7185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/11\/7185\/62628872\/7185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T06:25:16Z","timestamp":1743315916000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/175\/11\/7185\/8047241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,1]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.175.11.7185","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,12]]},"published":{"date-parts":[[2005,12,1]]}}}