{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:17:13Z","timestamp":1782782233832,"version":"3.54.5"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous studies of acute generalized exanthematous pustulosis, a peculiar drug hypersensitivity reaction, suggested that CXCL8-producing T cells regulate sterile, polymorphonuclear neutrophil-rich skin inflammations. In this study, we test the hypothesis of whether CXCL8-producing T cells are present in autoinflammatory diseases like pustular psoriasis and Behc\u0327et\u2019s disease. Immunohistochemistry of normal skin revealed few CD4+ and CD8+ T cells, few CXCL8+ cells, and no neutrophilic infiltration, whereas in acute exacerbations of atopic dermatitis, numerous CD4+ T cells but few CD8+ T cells, neutrophils, or CXCL8+ cells were detected. In contrast, a pronounced infiltration of neutrophils and of predominantly CD4+ T cells was observed in skin biopsies from pustular psoriasis, Behc\u0327et\u2019s disease, and acute generalized exanthematous pustulosis, with infiltrating T cells strongly positive for CXCL8 and the chemokine receptor CCR6. Skin-derived T cell clones from pustular skin reactions were positive for CCR6 but negative for CCR8 and secreted high amounts of CXCL8 and GM-CSF, often together with IFN-\u03b3 and TNF-\u03b1 after in vitro stimulation. Moreover, some skin-derived T cell clones from Behc\u0327et\u2019s disease and from pustular psoriasis predominantly produced CXCL8 and GM-CSF, but failed to secrete IL-5 and IFN-\u03b3. These cells might represent a particular subset as they differ from both Th1 as well as Th2 T cells and are associated with a unique, neutrophil-rich sterile inflammation. Our findings suggest that CXCL8\/GM-CSF-producing T cells may orchestrate neutrophil-rich pathologies of chronic autoinflammatory diseases like pustular psoriasis and Behc\u0327et\u2019s disease.<\/jats:p>","DOI":"10.4049\/jimmunol.175.11.7678","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:05:46Z","timestamp":1398042346000},"page":"7678-7686","source":"Crossref","is-referenced-by-count":101,"title":["T Cell-Regulated Neutrophilic Inflammation in Autoinflammatory Diseases"],"prefix":"10.1093","volume":"175","author":[{"given":"Monika","family":"Keller","sequence":"first","affiliation":[{"name":"Division of Allergology, Clinic of Rheumatology and Clinical Immunology\/Allergology, Inselspital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoi","family":"Spanou","sequence":"additional","affiliation":[{"name":"Division of Allergology, Clinic of Rheumatology and Clinical Immunology\/Allergology, Inselspital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schaerli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School, The CBR Institute for Biomedical Research , Boston MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Britschgi","sequence":"additional","affiliation":[{"name":"Division of Allergology, Clinic of Rheumatology and Clinical Immunology\/Allergology, Inselspital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Yawalkar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital , Inselspital, Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Seitz","sequence":"additional","affiliation":[{"name":"Division of Allergology, Clinic of Rheumatology and Clinical Immunology\/Allergology, Inselspital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Villiger","sequence":"additional","affiliation":[{"name":"Division of Allergology, Clinic of Rheumatology and Clinical Immunology\/Allergology, Inselspital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J","family":"Pichler","sequence":"additional","affiliation":[{"name":"Division of Allergology, Clinic of Rheumatology and Clinical Immunology\/Allergology, Inselspital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"2025032706022558100_R1","first-page":"771","volume-title":"Br. 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