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Although no clear evidence for SHC has been found in normal mouse B cells, transgenic mice carrying high-copy numbers of a gene construct designed to optimize detection of SHC have previously been shown to exhibit sequence transfers that resemble gene conversion events. However, these transgene sequence transfers could reflect multistep or reciprocal DNA recombination events rather than gene conversions. We now find in low-copy number transgenic mice that transgene sequence transfers can exhibit the unidirectional sequence information movement that is a hallmark of gene conversion. This indicates that gene conversion between V region sequences can occur in mouse B cells; we propose that the lack of efficient SHC contributions to Ab diversification in normal mice may be due, at least in part, to the particular pattern of V gene recombinational accessibility that occurs in differentiating mouse B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.175.12.8133","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:28:10Z","timestamp":1398032890000},"page":"8133-8137","source":"Crossref","is-referenced-by-count":8,"title":["Sequence Transfers between Variable Regions in a Mouse Antibody Transgene Can Occur by Gene Conversion"],"prefix":"10.1093","volume":"175","author":[{"given":"Nicole","family":"D\u2019Avirro","sequence":"first","affiliation":[{"name":"Program in Genetics, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Program in Immunology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Selsing","sequence":"additional","affiliation":[{"name":"Program in Genetics, Tufts University School of Medicine , Boston, MA 02111"},{"name":"Program in Immunology, Tufts University School of Medicine , Boston, MA 02111"},{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,12,15]]},"reference":[{"key":"2026020212204697700_R1","first-page":"575","volume-title":"Nature","year":"1983"},{"key":"2026020212204697700_R2","first-page":"1079","volume-title":"Science","year":"1987"},{"key":"2026020212204697700_R3","first-page":"5","volume-title":"Immunol. 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