{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:23:33Z","timestamp":1792718613243,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Invariant V\u03b114+ NKT cells are a specialized CD1-reactive T cell subset implicated in innate and adaptive immunity. We assessed whether V\u03b114+ NKT cells participated in the immune response against enteric Listeria monocytogenes infection in vivo. Using CD1d tetramers loaded with the synthetic lipid \u03b1-galactosylceramide (CD1d\/\u03b1GC), we found that splenic and hepatic V\u03b114+ NKT cells in C57BL\/6 mice were early producers of IFN-\u03b3 (but not IL-4) after L. monocytogenes infection. Adoptive transfer of V\u03b114+ NKT cells derived from TCR\u03b1\u00b0 V\u03b114-J\u03b118 transgenic (TCR\u03b1\u00b0V\u03b114Tg) mice into alymphoid Rag\u00b0\u03b3c\u00b0 mice demonstrated that V\u03b114+ NKT cells were capable of providing early protection against enteric L. monocytogenes infection with systemic production of IFN-\u03b3 and reduction of the bacterial burden in the liver and spleen. Rechallenge experiments demonstrated that previously immunized wild-type and J\u03b118\u00b0 mice, but not TCR\u03b1\u00b0 or TCR\u03b1\u00b0V\u03b114Tg mice, were able to mount adaptive responses to L. monocytogenes. These data demonstrate that V\u03b114+ NKT cells are able to participate in the early response against enteric L. monocytogenes through amplification of IFN-\u03b3 production, but are not essential for, nor capable of, mediating memory responses required to sterilize the host.<\/jats:p>","DOI":"10.4049\/jimmunol.175.2.1137","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T22:40:18Z","timestamp":1398206418000},"page":"1137-1144","source":"Crossref","is-referenced-by-count":52,"title":["Invariant V\u03b114+ NKT Cells Participate in the Early Response to Enteric\n                    <i>Listeria monocytogenes<\/i>\n                    Infection"],"prefix":"10.1093","volume":"175","author":[{"given":"Thomas","family":"Ranson","sequence":"first","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoi\u0308de, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 668, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Bregenholt","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoi\u0308de, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 668, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Lehuen","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 561, Hopital Cochin-Saint Vincent de Paul , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gaillot","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 411, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C","family":"Leite-de-Moraes","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Unite\u0301 Mixte Recherche 8147, Paris V, Institut de Recherche Necker-Enfants Malades , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u0301","family":"Herbelin","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Unite\u0301 Mixte Recherche 8147, Paris V, Institut de Recherche Necker-Enfants Malades , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Berche","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 411, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoi\u0308de, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 668, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,7,15]]},"reference":[{"key":"2026020212113478500_R1","first-page":"812","volume-title":"Nat. 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