{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:35:21Z","timestamp":1790937321119,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In normal B cell development, a large percentage of newly formed cells bear receptors with high levels of self-reactivity that must be tolerized before entry into the mature B cell pool. We followed the fate of self-reactive B cells expressing high affinity anti-hen egg lysozyme (HEL) Ag receptors exposed in vivo to membrane HEL in a setting in which the anti-HEL L chain was \u201cknocked-in\u201d at the endogenous L chain locus. These mice demonstrated extensive and efficient L chain receptor editing responses and had B cell numbers comparable to those found in animals lacking membrane Ag. BrdU labeling indicated that the time required for editing in response to membrane HEL was \u223c6 h. In mice transgenic for soluble HEL, anti-HEL B cells capable of editing showed evidence for both editing and anergy. These data identify receptor editing as a major physiologic mechanism by which highly self-reactive B cells are tolerized to membrane and soluble self-Ags.<\/jats:p>","DOI":"10.4049\/jimmunol.175.2.909","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T22:40:18Z","timestamp":1398206418000},"page":"909-916","source":"Crossref","is-referenced-by-count":72,"title":["In Vivo Assessment of the Relative Contributions of Deletion, Anergy, and Editing to B Cell Self-Tolerance"],"prefix":"10.1093","volume":"175","author":[{"given":"Keli L","family":"Hippen","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R","family":"Schram","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina E","family":"Tze","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc K","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Center for Immunology, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W","family":"Behrens","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota Medical School , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,7,15]]},"reference":[{"key":"2026020212174712700_R1","first-page":"1079","volume-title":"Science","year":"1987"},{"key":"2026020212174712700_R2","first-page":"751","volume-title":"Nature","year":"1996"},{"key":"2026020212174712700_R3","first-page":"1374","volume-title":"Science","year":"2003"},{"key":"2026020212174712700_R4","first-page":"2264","volume-title":"Proc. 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