{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:01:26Z","timestamp":1791295286855,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Shigella flexneri, an enteroinvasive Gram-negative bacterium, is responsible for the worldwide endemic form of bacillary dysentery. The host response to primary infection is characterized by the induction of an acute inflammation, which is accompanied by polymorphonuclear cell (PMN) infiltration, resulting in massive destruction of the colonic mucosa. However, PMN play a major role in the recovery from primary infection, by restricting the bacterial infection at the intestinal mucosa. In this study, we assessed the roles for T and NK cells in the control of primary S. flexneri infection, using an alymphoid mouse strain (Rag\u00b0\u03b3c\u00b0) devoid of B, T, and NK cells. Using the mouse pulmonary model of Shigella infection, we showed that alymphoid Rag\u00b0\u03b3c\u00b0 mice were highly susceptible to S. flexneri infection in comparison with wild-type (wt) mice. Whereas PMN recruitment upon infection was similar, macrophage recruitment and production of proinflammatory cytokines were significantly decreased in Rag\u00b0\u03b3c\u00b0 mice compared with wt mice. Upon selective engraftment of Rag\u00b0\u03b3c\u00b0 mice with polyclonal \u03b1\u03b2 T cells, but not with \u03b1\u03b2 T cells from IFN-\u03b3\u00b0, S. flexneri infection could be subsequently controlled. Rag\u00b0 mice devoid of B and T cells but harboring NK cells could control infection. Local IFN-\u03b3 production by T and NK cells recruited to the lung was demonstrated in S. flexneri-infected wt mice. These data demonstrate that both \u03b1\u03b2 T cells and NK cells contribute to the early control of S. flexneri infection through amplification of an inflammatory response. This cellular lymphocyte redundancy assures IFN-\u03b3 production, which is central to innate immunity against Shigella infection.<\/jats:p>","DOI":"10.4049\/jimmunol.175.3.1735","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:20:32Z","timestamp":1398036032000},"page":"1735-1740","source":"Crossref","is-referenced-by-count":74,"title":["Roles for T and NK Cells in the Innate Immune Response to\n                    <i>Shigella flexneri<\/i>"],"prefix":"10.1093","volume":"175","author":[{"given":"Karine","family":"Le-Barillec","sequence":"first","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoide, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 668, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Gamelas","family":"Magalhaes","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Corcuff","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoide, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 668, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Thuizat","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe J","family":"Sansonetti","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Phalipon","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Cytokines et De\u0301veloppement Lymphoide, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 668, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,8,1]]},"reference":[{"key":"2026020214053263700_R1","first-page":"953","volume-title":"Nat. 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