{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:01:14Z","timestamp":1772082074785,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>B cells present BCR V region-derived Id-peptides on their MHC class II molecules to Id-specific CD4+ T cells. Prolonged Id-driven T-B collaboration could cause autoimmune disease, but this possibility is difficult to test in normal individuals. We have investigated whether mice doubly transgenic for an Id+ Ig L chain and an Id-specific TCR develop autoimmune disease. Surprisingly, T cell tolerance was not complete in these mice because a low frequency of weakly Id-reactive CD4+ T cells accumulated with age. These escapee Id-specific T cells provided chronic help for Id+ B cells, resulting in a lethal systemic autoimmune disease including germinal center reactions, hypergammaglobulinemia, IgG autoantibodies, glomerulonephritis, arthritis, skin affection, and inflammatory bowel disease. Inflamed tissues contained foci of Id-driven T-B collaboration, with deposition of IgG and complement. The disease could be transferred with B and T cells. The results demonstrate a novel mechanism for development of autoimmune disease in which self-reactive Id+ B cells receive prolonged help from Id-specific T cells, thus bypassing the need for help from T cells recognizing conventional Ag.<\/jats:p>","DOI":"10.4049\/jimmunol.175.4.2391","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:33Z","timestamp":1398029553000},"page":"2391-2400","source":"Crossref","is-referenced-by-count":42,"title":["Systemic Autoimmune Disease Caused by Autoreactive B Cells That Receive Chronic Help from Ig V Region-Specific T Cells"],"prefix":"10.1093","volume":"175","author":[{"given":"Ludvig Andre\u0301","family":"Munthe","sequence":"first","affiliation":[{"name":"Institute of Immunology, University of Oslo, Rikshospitalet University Hospital , Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Corthay","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of Oslo, Rikshospitalet University Hospital , Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audun","family":"Os","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of Oslo, Rikshospitalet University Hospital , Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Zangani","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of Oslo, Rikshospitalet University Hospital , Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarne","family":"Bogen","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University of Oslo, Rikshospitalet University Hospital , Oslo ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,8,15]]},"reference":[{"key":"2026020212200511200_R1","first-page":"575","volume-title":"Nature","year":"1983"},{"key":"2026020212200511200_R2","first-page":"1218","volume-title":"Science","year":"1963"},{"key":"2026020212200511200_R3","first-page":"1373","volume-title":"Eur. J. Immunol.","year":"1986"},{"key":"2026020212200511200_R4","first-page":"282","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1989"},{"key":"2026020212200511200_R5","first-page":"2017","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020212200511200_R6","first-page":"201","volume-title":"Immunol. Rev.","year":"1998"},{"key":"2026020212200511200_R7","first-page":"1562","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020212200511200_R8","first-page":"464","volume-title":"Lupus","year":"1995"},{"key":"2026020212200511200_R9","first-page":"187","volume-title":"J. Clin. Immunol.","year":"2000"},{"key":"2026020212200511200_R10","first-page":"93","volume-title":"Eur. J. Immunol.","year":"1994"},{"key":"2026020212200511200_R11","first-page":"1786","volume-title":"Eur. J. Immunol.","year":"2005"},{"key":"2026020212200511200_R12","first-page":"767","volume-title":"Cell","year":"1991"},{"key":"2026020212200511200_R13","first-page":"357","volume-title":"EMBO J.","year":"1993"},{"key":"2026020212200511200_R14","first-page":"4043","volume-title":"Eur. J. Immunol.","year":"1999"},{"key":"2026020212200511200_R15","first-page":"3865","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020212200511200_R16","first-page":"337","volume-title":"Int. Rev. Immunol.","year":"1993"},{"key":"2026020212200511200_R17","first-page":"7476","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212200511200_R18","first-page":"1","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2026020212200511200_R19","first-page":"278","volume-title":"Eur. J. Immunol.","year":"1985"},{"key":"2026020212200511200_R20","first-page":"1037","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020212200511200_R21","first-page":"2391","volume-title":"Eur. J. Immunol.","year":"1991"},{"key":"2026020212200511200_R22","first-page":"1720","volume-title":"Science","year":"1990"},{"key":"2026020212200511200_R23","first-page":"2876","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2026020212200511200_R24","first-page":"1379","volume-title":"Eur. J. Immunol.","year":"1986"},{"key":"2026020212200511200_R25","first-page":"1569","volume-title":"J. Immunol.","year":"1994"},{"key":"2026020212200511200_R26","first-page":"265","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020212200511200_R27","first-page":"829","volume-title":"Immunity","year":"2000"},{"key":"2026020212200511200_R28","first-page":"18","volume-title":"Immunol. Rev.","year":"2001"},{"key":"2026020212200511200_R29","first-page":"147","volume-title":"Nat. Rev. Immunol.","year":"2001"},{"key":"2026020212200511200_R30","first-page":"2019","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1996"},{"key":"2026020212200511200_R31","first-page":"18","volume-title":"Eur. J. Immunol.","year":"1971"},{"key":"2026020212200511200_R32","first-page":"537","volume-title":"Nature","year":"1985"},{"key":"2026020212200511200_R33","first-page":"163","volume-title":"Nature","year":"1995"},{"key":"2026020212200511200_R34","first-page":"4037","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026020212200511200_R35","first-page":"1537","volume-title":"Science","year":"2001"},{"key":"2026020212200511200_R36","first-page":"32","volume-title":"Curr. Opin. Immunol.","year":"2001"},{"key":"2026020212200511200_R37","first-page":"461","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020212200511200_R38","first-page":"1641","volume-title":"Science","year":"2002"},{"key":"2026020212200511200_R39","first-page":"35","volume-title":"Adv. Exp. Med. Biol.","year":"2002"},{"key":"2026020212200511200_R40","first-page":"603","volume-title":"Nature","year":"2002"},{"key":"2026020212200511200_R41","first-page":"155","volume-title":"Nature","year":"1992"},{"key":"2026020212200511200_R42","first-page":"231","volume-title":"Immunol. Rev.","year":"1998"},{"key":"2026020212200511200_R43","first-page":"2671","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2026020212200511200_R44","first-page":"644","volume-title":"Curr. Opin. Immunol.","year":"2001"},{"key":"2026020212200511200_R45","first-page":"791","volume-title":"Curr. Opin. Immunol.","year":"2002"},{"key":"2026020212200511200_R46","first-page":"899","volume-title":"Nat. Med.","year":"2001"},{"key":"2026020212200511200_R47","first-page":"303","volume-title":"Cell","year":"1996"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/4\/2391\/62625672\/2391.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/4\/2391\/62625672\/2391.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:25:22Z","timestamp":1770053122000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/175\/4\/2391\/8036395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,8,15]]},"published-print":{"date-parts":[[2005,8,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.175.4.2391","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,8]]},"published":{"date-parts":[[2005,8]]}}}