{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:36:47Z","timestamp":1791164207476,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>WSX-1 (IL-27R) is a class I cytokine receptor with homology to gp130 and IL-12 receptors and is typically expressed on CD4+ T lymphocytes. Although previous reports have clarified that IL-27\/WSX-1 signaling plays critical roles in both Th1 differentiation and attenuation of cell activation and proinflammatory cytokine production during some bacterial or protozoan infections, little is known about the importance of WSX-1 in cytokine-mediated diseases of allergic origin. To this aim, we took advantage of WSX-1-deficient (WSX-1\u2212\/\u2212) mice and induced experimental asthma, in which Th2 cytokines are central modulators of the pathology. OVA-challenged WSX-1\u2212\/\u2212 mice showed marked enhancement of airway responsiveness with goblet cell hyperplasia, pulmonary eosinophil infiltration, and increased serum IgE levels compared with wild-type mice. Production of Th2 cytokines, which are largely responsible for the pathogenesis of asthma, was augmented in the lung or in the culture supernatants of peribronchial lymph node CD4+ T cells from WSX-1\u2212\/\u2212 mice compared with those from wild-type mice. Surprisingly, IFN-\u03b3 production was also enhanced in WSX-1\u2212\/\u2212 mice, albeit at a low concentration. The cytokine overproduction, thus, seems independent from the Th1-promoting property of WSX-1. These results demonstrated that IL-27\/WSX-1 also plays an important role in the down-regulation of airway hyper-reactivity and lung inflammation during the development of allergic asthma through its suppressive effect on cytokine production.<\/jats:p>","DOI":"10.4049\/jimmunol.175.4.2401","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:33Z","timestamp":1398029553000},"page":"2401-2407","source":"Crossref","is-referenced-by-count":90,"title":["Exacerbation of Experimental Allergic Asthma by Augmented Th2 Responses in WSX-1-Deficient Mice"],"prefix":"10.1093","volume":"175","author":[{"given":"Yoshiyuki","family":"Miyazaki","sequence":"first","affiliation":[{"name":"PRESTO, Japan Science and Technology Agency , Saitama ,","place":["Japan"]},{"name":"Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]},{"name":"Department of Biomolecular Sciences, Faculty of Medicine, Saga University , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Inoue","sequence":"additional","affiliation":[{"name":"Research Institute for Diseases of the Chest, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Research Institute for Diseases of the Chest, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Research Institute for Diseases of the Chest, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Nakano","sequence":"additional","affiliation":[{"name":"Research Institute for Diseases of the Chest, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Research Institute for Diseases of the Chest, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Graduate School of Medical Sciences, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"PRESTO, Japan Science and Technology Agency , Saitama ,","place":["Japan"]},{"name":"Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]},{"name":"Department of Biomolecular Sciences, Faculty of Medicine, Saga University , Saga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,8,15]]},"reference":[{"key":"2026020212125899500_R1","first-page":"295","volume-title":"Annu. Rev. Immunol.","year":"1994"},{"key":"2026020212125899500_R2","first-page":"255","volume-title":"Annu. Rev. Immunol.","year":"1999"},{"key":"2026020212125899500_R3","first-page":"175","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2026020212125899500_R4","first-page":"245","volume-title":"Nature","year":"1993"},{"key":"2026020212125899500_R5","first-page":"707","volume-title":"Science","year":"1991"},{"key":"2026020212125899500_R6","first-page":"1479","volume-title":"J. Clin. Invest.","year":"1992"},{"key":"2026020212125899500_R7","first-page":"43","volume-title":"J. Exp. Med.","year":"1988"},{"key":"2026020212125899500_R8","first-page":"258","volume-title":"Immunology","year":"1990"},{"key":"2026020212125899500_R9","first-page":"3697","volume-title":"Blood","year":"1994"},{"key":"2026020212125899500_R10","first-page":"845","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1997"},{"key":"2026020212125899500_R11","first-page":"2261","volume-title":"Science","year":"1998"},{"key":"2026020212125899500_R12","first-page":"2258","volume-title":"Science","year":"1998"},{"key":"2026020212125899500_R13","first-page":"885","volume-title":"Nat. Med.","year":"2002"},{"key":"2026020212125899500_R14","first-page":"787","volume-title":"Nature","year":"1996"},{"key":"2026020212125899500_R15","first-page":"573","volume-title":"J. Exp. Med.","year":"1993"},{"key":"2026020212125899500_R16","first-page":"1309","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020212125899500_R17","first-page":"82","volume-title":"Biochem. Biophys. Res. Commun.","year":"1998"},{"key":"2026020212125899500_R18","first-page":"916","volume-title":"Nature","year":"2000"},{"key":"2026020212125899500_R19","first-page":"569","volume-title":"Immunity","year":"2001"},{"key":"2026020212125899500_R20","first-page":"779","volume-title":"Immunity","year":"2002"},{"key":"2026020212125899500_R21","first-page":"4886","volume-title":"J. Immunol.","year":"2003"},{"key":"2026020212125899500_R22","first-page":"4672","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212125899500_R23","first-page":"645","volume-title":"Immunity","year":"2003"},{"key":"2026020212125899500_R24","first-page":"657","volume-title":"Immunity","year":"2003"},{"key":"2026020212125899500_R25","first-page":"3534","volume-title":"J. Immunol.","year":"2005"},{"key":"2026020212125899500_R26","first-page":"233","volume-title":"Virus Res.","year":"1995"},{"key":"2026020212125899500_R27","first-page":"253","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"2000"},{"key":"2026020212125899500_R28","first-page":"271","volume-title":"N. Engl. J. Med.","year":"1989"},{"key":"2026020212125899500_R29","first-page":"885","volume-title":"Int. Immunol.","year":"1993"},{"key":"2026020212125899500_R30","first-page":"302","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020212125899500_R31","first-page":"683","volume-title":"Annu. Rev. Immunol.","year":"2001"},{"key":"2026020212125899500_R32","first-page":"46","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020212125899500_R33","first-page":"587","volume-title":"Cell","year":"1997"},{"key":"2026020212125899500_R34","first-page":"655","volume-title":"Cell","year":"2000"},{"key":"2026020212125899500_R35","first-page":"215","volume-title":"J. Allergy Clin. Immunol.","year":"1999"},{"key":"2026020212125899500_R36","first-page":"410","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2026020212125899500_R37","first-page":"13003","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026020212125899500_R38","first-page":"1047","volume-title":"Nat. Med.","year":"2003"},{"key":"2026020212125899500_R39","first-page":"7635","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212125899500_R40","first-page":"5626","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212125899500_R41","first-page":"336","volume-title":"Science","year":"2002"},{"key":"2026020212125899500_R42","first-page":"3590","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212125899500_R43","first-page":"3770","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020212125899500_R44","first-page":"3645","volume-title":"J. Immunol.","year":"2003"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/4\/2401\/62627187\/2401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/4\/2401\/62627187\/2401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:15:41Z","timestamp":1770052541000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/175\/4\/2401\/8035799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,8,15]]},"published-print":{"date-parts":[[2005,8,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.175.4.2401","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,8]]},"published":{"date-parts":[[2005,8]]}}}