{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:01:00Z","timestamp":1791104460705,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Several reports suggest that activated airway smooth muscle (ASM) cells are capable of generating various proinflammatory mediators, including cytokines and chemokines. However, little is known about the mechanism involved in this process. In this regard, we have examined the expression and the role of the high affinity IgE receptor (Fc\u03b5RI) by ASM cells. Human ASM cells were found to constitutively express transcripts coding for \u03b1, \u03b2, and \u03b3 subunits of Fc\u03b5RI. Flow cytometry and Western blot analysis confirmed the expression of Fc\u03b5RI \u03b1-chain protein. Interestingly, Fc\u03b5RI \u03b1-chain immunoreactivity was also demonstrated in smooth muscle within bronchial biopsies of asthmatic subjects. Cross-linking of Fc\u03b5RI induced mobilization of free calcium in ASM cells, one of the critical signals to trigger smooth muscle contraction. Furthermore, cultured ASM cells released IL-4, IL-13, IL-5, and eotaxin but not IFN-\u03b3, when sensitized with IgE followed by anti-IgE Ab cross-linking. The addition of anti-Fc\u03b5RI \u03b1-chain Abs directed against IgE binding site inhibited this release. Taken together, these results suggest a potential new and important mechanism by which ASM cells may participate in airway inflammation and bronchoconstriction associated with allergic asthma.<\/jats:p>","DOI":"10.4049\/jimmunol.175.4.2613","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:33Z","timestamp":1398029553000},"page":"2613-2621","source":"Crossref","is-referenced-by-count":76,"title":["Human Airway Smooth Muscle Cells Express the High Affinity Receptor for IgE (Fc\u03b5RI): A Critical Role of Fc\u03b5RI in Human Airway Smooth Muscle Cell Function"],"prefix":"10.1093","volume":"175","author":[{"given":"Abdelilah Soussi","family":"Gounni","sequence":"first","affiliation":[{"name":"Department of Immunology, Department of Physiology, Section of Respiratory Diseases, Faculty of Medicine, University of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Wellemans","sequence":"additional","affiliation":[{"name":"Ste-Justine Hospital, Research Centre, University of Montreal , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Department of Physiology, Section of Respiratory Diseases, Faculty of Medicine, University of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Bellesort","sequence":"additional","affiliation":[{"name":"Ste-Justine Hospital, Research Centre, University of Montreal , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamrouz","family":"Kassiri","sequence":"additional","affiliation":[{"name":"Department of Immunology, Department of Physiology, Section of Respiratory Diseases, Faculty of Medicine, University of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gangloff","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Immunologie et Microbiologie, Faculte\u0301 de Pharmacie, IFR53 Biomole\u0301cules , Reims ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Guenounou","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Immunologie et Microbiologie, Faculte\u0301 de Pharmacie, IFR53 Biomole\u0301cules , Reims ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Halayko","sequence":"additional","affiliation":[{"name":"Department of Immunology, Department of Physiology, Section of Respiratory Diseases, Faculty of Medicine, University of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qutayba","family":"Hamid","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories and Departments of Medicine and Pathology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchaib","family":"Lamkhioued","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Immunologie et Microbiologie, Faculte\u0301 de Pharmacie, IFR53 Biomole\u0301cules , Reims ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,8,15]]},"reference":[{"key":"2026020212124784600_R1","first-page":"5","volume-title":"Ciba Found Symp.","year":"1997"},{"key":"2026020212124784600_R2","first-page":"S35","volume-title":"Am. 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