{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:44:01Z","timestamp":1770097441117,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hemopoietic stem and progenitor cells ordinarily residing within bone marrow are released into the circulation following G-CSF administration. Such mobilization has a great clinical impact on hemopoietic stem cell transplantation. Underlying mechanisms are incompletely understood, but may involve G-CSF-induced modulation of chemokines, adhesion molecules, and proteolytic enzymes. We studied G-CSF-induced mobilization of CD34+CD10+CD19\u2212Lin\u2212 and CD34+CD10+CD19+Lin\u2212 cells (early B and pro-B cells, respectively). These mobilized lymphoid populations could differentiate only into B\/NK cells or B cells equivalent to their marrow counterparts. Mobilized lymphoid progenitors expressed lymphoid- but not myeloid-related genes including the G-CSF receptor gene, and displayed the same pattern of Ig rearrangement status as their bone marrow counterparts. Decreased expression of VLA-4 and CXCR-4 on mobilized lymphoid progenitors as well as multipotent and myeloid progenitors indicated lineage-independent involvement of these molecules in G-CSF-induced mobilization. The results suggest that by acting through multiple trans-acting signals, G-CSF can mobilize not only myeloid-committed populations but a variety of resident marrow cell populations including lymphoid progenitors.<\/jats:p>","DOI":"10.4049\/jimmunol.175.4.2647","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:32:33Z","timestamp":1398029553000},"page":"2647-2654","source":"Crossref","is-referenced-by-count":23,"title":["Mobilization of Human Lymphoid Progenitors after Treatment with Granulocyte Colony-Stimulating Factor"],"prefix":"10.1093","volume":"175","author":[{"given":"Rie","family":"Imamura","sequence":"first","affiliation":[{"name":"Blood Transfusion Service, Kyushu University Hospital, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]},{"name":"Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]},{"name":"Second Department of Internal Medicine, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goichi","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Kamezaki","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service, Kyushu University Hospital, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]},{"name":"Medicine and Biosystemic 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,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kato","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Takase","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service, Kyushu University Hospital, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]},{"name":"Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Kurume University School of Medicine , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Numata","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service, Kyushu University Hospital, Kurume University School of Medicine , Fukuoka 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