{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:10:40Z","timestamp":1791202240625,"version":"4.2.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>EBV infects a large proportion of the human population worldwide and is one of the major viruses with human B lymphocyte tropism. It can immortalize human B lymphocytes and controls their resistance to apoptosis. EBV infection is associated with several lymphomas, including Burkitt\u2019s lymphoma. In this report we show that EBV infection leads to the post-transcriptional down-regulation of expression of the proapoptotic protein Bim. This process involves the phosphorylation of BimEL by the constitutive EBV-activated kinase ERK1\/2, followed by its degradation through the proteasome pathway. We also show that ectopic expression of BimEL in EBV-positive Burkitt\u2019s lymphoma cells can enhance the sensitivity of these cells to serum deprivation-dependent apoptosis. Thus, EBV-mediated resistance to growth factor deprivation in human B lymphocytes is dependent on BimEL expression. Our data suggest that this regulatory pathway is an important contributor to the oncogenic potential of EBV.<\/jats:p>","DOI":"10.4049\/jimmunol.175.5.2968","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T13:44:04Z","timestamp":1398347044000},"page":"2968-2973","source":"Crossref","is-referenced-by-count":48,"title":["EBV Infection of Human B Lymphocytes Leads to Down-Regulation of Bim Expression: Relationship to Resistance to Apoptosis"],"prefix":"10.1093","volume":"175","author":[{"given":"Cyril","family":"Clybouw","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 542, Universite\u0301 Paris-Sud, Ho\u0302pital Paul Brousse , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchra","family":"Mchichi","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 542, Universite\u0301 Paris-Sud, Ho\u0302pital Paul Brousse , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahul","family":"Mouhamad","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 542, Universite\u0301 Paris-Sud, Ho\u0302pital Paul Brousse , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie The\u0301re\u0300se","family":"Auffredou","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 542, Universite\u0301 Paris-Sud, Ho\u0302pital Paul Brousse , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Franc\u0327oise","family":"Bourgeade","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 542, Universite\u0301 Paris-Sud, Ho\u0302pital Paul Brousse , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Brown University , Providence, RI 02905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Leca","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 542, Universite\u0301 Paris-Sud, Ho\u0302pital Paul Brousse , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aime\u0301","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 542, Universite\u0301 Paris-Sud, Ho\u0302pital Paul Brousse , Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"2025032705425949300_R1","first-page":"109","volume-title":"Virus Res.","year":"2002"},{"key":"2025032705425949300_R2","first-page":"801","volume-title":"Nat. Rev. Immunol.","year":"2003"},{"key":"2025032705425949300_R3","first-page":"405","volume-title":"Immunity","year":"1998"},{"key":"2025032705425949300_R4","first-page":"8479","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2025032705425949300_R5","first-page":"1735","volume-title":"Science","year":"1999"},{"key":"2025032705425949300_R6","first-page":"922","volume-title":"Nature","year":"2002"},{"key":"2025032705425949300_R7","first-page":"1119","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2025032705425949300_R8","first-page":"6164","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2004"},{"key":"2025032705425949300_R9","first-page":"6785","volume-title":"Oncogene","year":"2003"},{"key":"2025032705425949300_R10","first-page":"2084","volume-title":"J. Immunol.","year":"2004"},{"key":"2025032705425949300_R11","first-page":"1047","volume-title":"J. Immunol.","year":"1995"},{"key":"2025032705425949300_R12","first-page":"1615","volume-title":"Oncogene","year":"1995"},{"key":"2025032705425949300_R13","first-page":"1107","volume-title":"Cell","year":"1991"},{"key":"2025032705425949300_R14","first-page":"629","volume-title":"Neuron","year":"2001"},{"key":"2025032705425949300_R15","first-page":"615","volume-title":"Neuron","year":"2001"},{"key":"2025032705425949300_R16","first-page":"1201","volume-title":"Curr. Biol.","year":"2000"},{"key":"2025032705425949300_R17","first-page":"5024","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032705425949300_R18","first-page":"287","volume-title":"Mol. Cell","year":"1999"},{"key":"2025032705425949300_R19","first-page":"49511","volume-title":"J. Biol. Chem.","year":"2002"},{"key":"2025032705425949300_R20","first-page":"2432","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2025032705425949300_R21","first-page":"854","volume-title":"Mol. Cell. Biol.","year":"2001"},{"key":"2025032705425949300_R22","first-page":"18811","volume-title":"J. Biol. Chem.","year":"2003"},{"key":"2025032705425949300_R23","first-page":"983","volume-title":"Mol. Immunol.","year":"2003"},{"key":"2025032705425949300_R24","first-page":"905","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2025032705425949300_R25","first-page":"8913","volume-title":"J. Virol.","year":"1999"},{"key":"2025032705425949300_R26","first-page":"9556","volume-title":"J. Virol.","year":"2002"},{"key":"2025032705425949300_R27","first-page":"384","volume-title":"EMBO J.","year":"1998"},{"key":"2025032705425949300_R28","first-page":"3577","volume-title":"Mol. Cell. Biol.","year":"2002"},{"key":"2025032705425949300_R29","first-page":"7863","volume-title":"Oncogene","year":"2004"},{"key":"2025032705425949300_R30","first-page":"1281","volume-title":"Oncogene","year":"2003"},{"key":"2025032705425949300_R31","first-page":"6653","volume-title":"EMBO J.","year":"2003"},{"key":"2025032705425949300_R32","first-page":"2393","volume-title":"Blood","year":"2003"},{"key":"2025032705425949300_R33","first-page":"15313","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2004"},{"key":"2025032705425949300_R34","first-page":"6801","volume-title":"EMBO J.","year":"2002"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/5\/2968\/62623560\/2968.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/5\/2968\/62623560\/2968.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T05:52:11Z","timestamp":1743313931000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/175\/5\/2968\/8036166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,1]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.175.5.2968","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,9]]},"published":{"date-parts":[[2005,9,1]]}}}