{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:30:21Z","timestamp":1790479821795,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>During inflammation, chemokines are conductors of lymphocyte trafficking. The chemokine CXCL10 is expressed early after virus infection. In a virus-induced mouse model for type 1 diabetes, CXCL10 blockade abrogated disease by interfering with trafficking of autoaggressive lymphocytes to the pancreas. We have generated transgenic rat insulin promotor (RIP)-CXCL10 mice expressing CXCL10 in the \u03b2 cells of the islets of Langerhans to evaluate how bystander inflammation influences autoimmunity. RIP-CXCL10 mice have islet infiltrations by mononuclear cells and limited impairment of \u03b2 cell function, but not spontaneous diabetes. RIP-CXCL10 mice crossed to RIP-nucleoprotein (NP) mice expressing the NP of the lymphocytic choriomeningitis virus in the \u03b2 cells had massively accelerated type 1 diabetes after lymphocytic choriomeningitis virus infection. Mechanistically, we found a drastic increase in NP-specific, autoaggressive CD8 T cells in the pancreas after infection. In situ staining with H-2Db(NP396) tetramers revealed islet infiltration by NP-specific CD8 T cells in RIP-NP-CXCL10 mice early after infection. Our results indicate that CXCL10 expression accelerates the autoimmune process by enhancing the migration of Ag-specific lymphocytes to their target site.<\/jats:p>","DOI":"10.4049\/jimmunol.175.6.3516","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:07:11Z","timestamp":1398042431000},"page":"3516-3524","source":"Crossref","is-referenced-by-count":103,"title":["Islet-Specific Expression of CXCL10 Causes Spontaneous Islet Infiltration and Accelerates Diabetes Development"],"prefix":"10.1093","volume":"175","author":[{"given":"Antje","family":"Rhode","sequence":"first","affiliation":[{"name":"Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E","family":"Pauza","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine , Springfield, IL 62702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Barral","sequence":"additional","affiliation":[{"name":"Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B A","family":"Oldstone","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Neuropharmacology and Department of Infectology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G","family":"von Herrath","sequence":"additional","affiliation":[{"name":"Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Christen","sequence":"additional","affiliation":[{"name":"Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology , San Diego, CA 92121"},{"name":"Pharmacenter, Johann Wolfgang Goethe University , Frankfurt-am-Main ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,15]]},"reference":[{"key":"2025032615430924000_R1","first-page":"1414","volume-title":"Nat. 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