{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:48:26Z","timestamp":1783975706284,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>NF-\u03baB\/Rel transcription factors, implicated in inflammatory and immune responses against pathogens, are regulated by I\u03baB proteins. The physiological and molecular function of the I\u03baB family member Bcl-3 is understood only poorly. In this study, the role of Bcl-3 in an innate immune response was examined by gene targeting. We demonstrate that Bcl-3\u2212\/\u2212 mice are highly susceptible to Listeria monocytogenes infection. This correlates with diminished production of IL-12 p70 and IFN-\u03b3 in vivo, which is mainly due to elevated synthesis of IL-10. Isolated peritoneal macrophages from Bcl-3\u2212\/\u2212 mice also produce elevated amounts of IL-10, which inhibit IL-12 p70 synthesis in an autocrine fashion. Thus, these data establish Bcl-3 as an inhibitor of IL-10 expression in macrophages. Furthermore, we show that Bcl-3 is not implicated in IL-10 mRNA stabilization but regulates the initiation of IL-10 transcription. Taken together, our results show that an essential function of Bcl-3 during an innate immune response against bacteria is to inhibit transcription of the IL-10 gene in macrophages.<\/jats:p>","DOI":"10.4049\/jimmunol.175.6.3560","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:07:11Z","timestamp":1398028031000},"page":"3560-3568","source":"Crossref","is-referenced-by-count":33,"title":["The I\u03baB Protein Bcl-3 Negatively Regulates Transcription of the\n                    <i>IL-10<\/i>\n                    Gene in Macrophages"],"prefix":"10.1093","volume":"175","author":[{"given":"Marc","family":"Riemann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Endres","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Liptay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Ulm , Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Du\u0308sseldorf , Du\u0308sseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland M","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Technical University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,15]]},"reference":[{"key":"2026020212144297000_R1","first-page":"225","volume-title":"Annu. 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