{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:36:32Z","timestamp":1790890592941,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The severity of infection with Streptococcus pyogenes is strongly influenced by the host\u2019s genetics. This observation extends to the murine model of streptococcal infection, where the background of the mouse strain determines the infection outcome (BALB\/c are resistant, whereas C3H\/HeN are susceptible). To determine the extent to which the MHC complex (H2) contributed to diseases susceptibility, the response to S. pyogenes of congenic BALB mice from a resistant background (BALB\/c), but carrying the H2k region of susceptible C3H\/HeN mice (BALB\/k), was examined. BALB\/k were as susceptible as the H2 donor strain (C3H\/HeN). Linkage analysis performed in F2 backcross ([BALB\/c \u00d7 C3H\/HeN] \u00d7 BALB\/c) mice confirmed the presence of a susceptibility locus within the H2 region on proximal chromosome 17. The possibility that modulation of T cell responses to streptococcal superantigens (GAS-SAgs) by different H2 haplotypes may influence disease severity was examined. BALB\/k exhibited a significantly stronger response at the level of cell proliferation and cytokine production to GAS-SAgs than did BALB\/c mice. However, the fact that T cell-deficient SCID-C3H\/HeN mice also exhibited a susceptible phenotype suggests a more important contribution of innate effector cells to disease susceptibility. Lower transcriptional levels of certain inflammation-related regulatory genes located on chromosome 17 were detected in macrophages from susceptible than in those from resistant mice in response to infection. These results suggest that susceptibility to S. pyogenes may be associated with an altered transcription of specific genes that may compromise the endogenous regulatory processes controlling the inflammatory cascade and favor the progression to sepsis.<\/jats:p>","DOI":"10.4049\/jimmunol.175.6.3862","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:07:11Z","timestamp":1398042431000},"page":"3862-3872","source":"Crossref","is-referenced-by-count":17,"title":["The Role of the MHC on Resistance to Group A Streptococci in Mice"],"prefix":"10.1093","volume":"175","author":[{"given":"Oliver","family":"Goldmann","sequence":"first","affiliation":[{"name":"Infection Immunology Group, Gesellschaft fur Biotechnologishe Forschung-German Research Center for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lengeling","sequence":"additional","affiliation":[{"name":"Infection Genetics Group, Department of Microbial Pathogenesis and Vaccine Research, Gesellschaft fur Biotechnologishe Forschung-German Research Center for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bo\u0308se","sequence":"additional","affiliation":[{"name":"Infection Genetics Group, Department of Microbial Pathogenesis and Vaccine Research, Gesellschaft fur Biotechnologishe Forschung-German Research Center for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Bloecker","sequence":"additional","affiliation":[{"name":"Department of Genome Analysis, Gesellschaft fur Biotechnologishe Forschung-German Research Center for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Geffers","sequence":"additional","affiliation":[{"name":"Array Facility, Gesellschaft fur Biotechnologishe Forschung-German Research Center for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gursharan S","family":"Chhatwal","sequence":"additional","affiliation":[{"name":"Microbial Pathogenesis Group, Department of Microbial Pathogenesis and Vaccine Research, Gesellschaft fur Biotechnologishe Forschung-German Research Center for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Medina","sequence":"additional","affiliation":[{"name":"Infection Immunology Group, Gesellschaft fur Biotechnologishe Forschung-German Research Center for Biotechnology , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,15]]},"reference":[{"key":"2025032615431064600_R1","first-page":"470","volume-title":"Clin. 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