{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:06:58Z","timestamp":1793725618455,"version":"4.6.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>C57BL\/6 mice infected with the helminth Schistosoma mansoni develop small hepatic granulomas around parasite eggs, but concomitant immunization with soluble schistosome egg Ags (SEA) in CFA (SEA\/CFA) causes marked exacerbation of the lesions in a Th1-dominated environment characterized by high levels of IFN-\u03b3. We explored the cause of the severe immunopathology by using IL-12p40\u2212\/\u2212 and IL-12p35\u2212\/\u2212 mice. SEA\/CFA-immunized IL-12p40\u2212\/\u2212 mice, incapable of making IL-12 or IL-23, were completely resistant to high pathology, and their SEA-stimulated lymphoid cells failed to secrete significant IFN-\u03b3 or IL-17. In contrast, SEA\/CFA-immunized IL-12p35\u2212\/\u2212 mice, able to make IL-23 but not IL-12, developed severe lesions that correlated with high levels of IL-17, low IFN-\u03b3, and an expansion of activated CD4 T cells with a CD44high\/CD62Llow memory phenotype. In vivo administration of neutralizing anti-IL-17 mAb markedly inhibited hepatic granulomatous inflammation. Importantly, CBA mice, a naturally high pathology strain, also displayed elevated IL-17 levels comparable to those seen in the SEA\/CFA-immunized BL\/6 mice, and their lesions were similarly reduced by in vivo treatment with anti-IL-17. Our findings indicate that an IL-17-producing T cell population, likely driven by IL-23, significantly contributes to severe immunopathology in schistosomiasis.<\/jats:p>","DOI":"10.4049\/jimmunol.175.6.3920","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:07:11Z","timestamp":1398042431000},"page":"3920-3926","source":"Crossref","is-referenced-by-count":151,"title":["Severe CD4 T Cell-Mediated Immunopathology in Murine Schistosomiasis Is Dependent on IL-12p40 and Correlates with High Levels of IL-17"],"prefix":"10.1093","volume":"175","author":[{"given":"Laura I","family":"Rutitzky","sequence":"first","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Lopes da Rosa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel J","family":"Stadecker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,15]]},"reference":[{"key":"2025032615425765400_R1","first-page":"499","volume-title":"Nat. Rev. Immunol.","year":"2002"},{"key":"2025032615425765400_R2","first-page":"269","volume-title":"Trends Immunol.","year":"2003"},{"key":"2025032615425765400_R3","first-page":"2884","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032615425765400_R4","first-page":"4643","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032615425765400_R5","first-page":"4040","volume-title":"Infect. Immun.","year":"2003"},{"key":"2025032615425765400_R6","first-page":"777","volume-title":"J. Immunol.","year":"1997"},{"key":"2025032615425765400_R7","first-page":"880","volume-title":"Eur. J. Immunol.","year":"2003"},{"key":"2025032615425765400_R8","first-page":"85","volume-title":"Am. J. Trop. Med. Hyg.","year":"1987"},{"key":"2025032615425765400_R9","first-page":"435","volume-title":"J. Immunol.","year":"2005"},{"key":"2025032615425765400_R10","first-page":"13243","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2025032615425765400_R11","first-page":"713","volume-title":"Annu. Rev. Immunol.","year":"2003"},{"key":"2025032615425765400_R12","first-page":"715","volume-title":"Immunity","year":"2000"},{"key":"2025032615425765400_R13","first-page":"641","volume-title":"Immunity","year":"2003"},{"key":"2025032615425765400_R14","first-page":"5699","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032615425765400_R15","first-page":"1910","volume-title":"J. Biol. Chem.","year":"2003"},{"key":"2025032615425765400_R16","first-page":"1265","volume-title":"J. Allergy Clin. Immunol.","year":"2004"},{"key":"2025032615425765400_R17","first-page":"467","volume-title":"Immunity","year":"2004"},{"key":"2025032615425765400_R18","first-page":"233","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2025032615425765400_R19","first-page":"744","volume-title":"Nature","year":"2003"},{"key":"2025032615425765400_R20","first-page":"1951","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2025032615425765400_R21","first-page":"96","volume-title":"Immunol. Rev.","year":"2004"},{"key":"2025032615425765400_R22","first-page":"488","volume-title":"J. Exp. Med.","year":"1970"},{"key":"2025032615425765400_R23","first-page":"1859","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032615425765400_R24","first-page":"2593","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032615425765400_R25","first-page":"650","volume-title":"Arthritis Rheum.","year":"2004"},{"key":"2025032615425765400_R26","first-page":"3437","volume-title":"Infect. Immun.","year":"2003"},{"key":"2025032615425765400_R27","first-page":"3457","volume-title":"Infect. Immun.","year":"1997"},{"key":"2025032615425765400_R28","first-page":"3999","volume-title":"J. Immunol.","year":"1995"},{"key":"2025032615425765400_R29","first-page":"257","volume-title":"Scand. J. Immunol.","year":"1996"},{"key":"2025032615425765400_R30","first-page":"169","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2025032615425765400_R31","first-page":"604","volume-title":"Nature","year":"1992"},{"key":"2025032615425765400_R32","first-page":"5461","volume-title":"J. Immunol.","year":"1993"},{"key":"2025032615425765400_R33","first-page":"594","volume-title":"J. Immunol.","year":"1977"},{"key":"2025032615425765400_R34","first-page":"884","volume-title":"Eur. J. Immunol.","year":"1995"},{"key":"2025032615425765400_R35","first-page":"1170","volume-title":"Eur. J. Immunol.","year":"1997"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/6\/3920\/62625055\/3920.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/6\/3920\/62625055\/3920.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T16:26:15Z","timestamp":1743265575000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/175\/6\/3920\/8036178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,9,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.175.6.3920","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,9]]},"published":{"date-parts":[[2005,9]]}}}