{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:13:26Z","timestamp":1789514006025,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dengue virus (DEN), a flavivirus, causes dengue fever and dengue hemorrhagic fever\/dengue shock syndrome, the most common mosquito-borne viral illnesses in humans worldwide. In this study, using STAT1\u2212\/\u2212 mice bearing two different mutant stat1 alleles in the 129\/Sv\/Ev background, we demonstrate that IFNR-dependent control of primary DEN infection involves both STAT1-dependent and STAT1-independent mechanisms. The STAT1 pathway is necessary for clearing the initial viral load, whereas the STAT1-independent pathway controls later viral burden and prevents DEN disease in mice. The STAT1-independent responses in mice with primary DEN infection included the early activation of B and NK cells as well as the up-regulation of MHC class I molecules on macrophages and dendritic cells. Infection of bone marrow-derived dendritic cell cultures with either DEN or Sindbis virus, another positive-strand RNA virus, confirmed the early vs late natures of the STAT1-dependent and STAT1-independent pathways. Collectively, these data begin to define the nature of the STAT1-dependent vs the STAT1-independent pathway in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.175.6.3946","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:07:11Z","timestamp":1398042431000},"page":"3946-3954","source":"Crossref","is-referenced-by-count":117,"title":["Critical Roles for Both STAT1-Dependent and STAT1-Independent Pathways in the Control of Primary Dengue Virus Infection in Mice"],"prefix":"10.1093","volume":"175","author":[{"given":"Sujan","family":"Shresta","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, School of Public Health, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L","family":"Sharar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Public Health, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil M","family":"Prigozhin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Public Health, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M","family":"Snider","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Public Health, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Robert","family":"Beatty","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Public Health, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Public Health, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,15]]},"reference":[{"key":"2025032615430333100_R1","first-page":"1043","volume-title":"Fields Virology","year":"2001"},{"key":"2025032615430333100_R2","first-page":"476","volume-title":"Science","year":"1988"},{"key":"2025032615430333100_R3","first-page":"1","volume-title":"Virology","year":"1999"},{"key":"2025032615430333100_R4","first-page":"397","volume-title":"Adv. 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