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In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediated Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.<\/jats:p>","DOI":"10.4049\/jimmunol.175.7.4301","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:01Z","timestamp":1398034501000},"page":"4301-4308","source":"Crossref","is-referenced-by-count":66,"title":["Virus-Induced Inhibition of CD1d1-Mediated Antigen Presentation: Reciprocal Regulation by p38 and ERK"],"prefix":"10.1093","volume":"175","author":[{"given":"Gourapura J","family":"Renukaradhya","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Walther Oncology Center , Indianapolis, IN 46202"},{"name":"Walther Cancer Institute , Indianapolis, IN 46208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya J Roberts","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Walther Oncology Center , Indianapolis, IN 46202"},{"name":"Walther Cancer Institute , Indianapolis, IN 46208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood A","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Walther Oncology Center , Indianapolis, IN 46202"},{"name":"Walther Cancer Institute , Indianapolis, IN 46208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Walther Oncology Center , Indianapolis, IN 46202"},{"name":"Walther Cancer Institute , Indianapolis, IN 46208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California , Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn","family":"Gervay-Hague","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California , Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy R","family":"Brutkiewicz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Walther Oncology Center , Indianapolis, IN 46202"},{"name":"Walther Cancer Institute , Indianapolis, IN 46208"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2026020212133219200_R1","first-page":"323","volume-title":"Annu. 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