{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:19:20Z","timestamp":1791062360029,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The characterization of antiviral CTL responses has largely been limited to assessing Ag-specific immune responses in the peripheral blood. Consequently, there is an incomplete understanding of the cellular immune responses at mucosal sites where many viruses enter and initially replicate and how the Ag specificity and activation status of CTL derived from these mucosal sites may differ from that of blood-derived CTL. In this study, we show that EBV-specific CTL responses in the tonsils are of comparable specificity and breadth but of a significantly higher magnitude compared with responses in the peripheral blood. EBV-specific, tonsil-resident, but not PBMC-derived, T cells expressed the integrin\/activation marker CD103 (\u03b1E\u03b27), consistent with the detection of its ligand, E-cadherin, on tonsillar squamous cells. These CD8-positive, CD103-positive, tonsil-derived CTL were largely CCR7- and CD45RA- negative effector-memory cells and responded to lower Ag concentrations in in vitro assays than their CD103-negative PBMC-derived counterparts. Thus, EBV-specific CTL in the tonsil, a crucial site for EBV entry and replication, are of greater magnitude and phenotypically distinct from CTL in the peripheral blood and may be important for effective control of this orally transmitted virus.<\/jats:p>","DOI":"10.4049\/jimmunol.175.7.4355","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:01Z","timestamp":1398034501000},"page":"4355-4362","source":"Crossref","is-referenced-by-count":59,"title":["\u03b1E\u03b27 (CD103) Expression Identifies a Highly Active, Tonsil-Resident Effector-Memory CTL Population"],"prefix":"10.1093","volume":"175","author":[{"given":"Tonia","family":"Woodberry","sequence":"first","affiliation":[{"name":"Partners AIDS Research Center, Massachusetts General Hospital , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J","family":"Suscovich","sequence":"additional","affiliation":[{"name":"Partners AIDS Research Center, Massachusetts General Hospital , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah M","family":"Henry","sequence":"additional","affiliation":[{"name":"Partners AIDS Research Center, Massachusetts General Hospital , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"August","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery, Massachusetts General Hospital , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Waring","sequence":"additional","affiliation":[{"name":"Partners AIDS Research Center, Massachusetts General Hospital , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"New England Primate Research Center, Harvard Medical School , Southborough, MA 01772"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Hess","sequence":"additional","affiliation":[{"name":"University Hospital , Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery L","family":"Kutok","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon C","family":"Aster","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Wang","sequence":"additional","affiliation":[{"name":"Channing Laboratories, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T","family":"Scadden","sequence":"additional","affiliation":[{"name":"Partners AIDS Research Center, Massachusetts General Hospital , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brander","sequence":"additional","affiliation":[{"name":"Partners AIDS Research Center, Massachusetts General Hospital , Boston, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2026020212195205000_R1","first-page":"1840","volume-title":"J. 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