{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:37:33Z","timestamp":1792726653642,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We identified committed T cell progenitors (CTPs) in the mouse bone marrow that have not rearranged the TCR\u03b2 gene; express a variety of genes associated with commitment to the T cell lineage, including GATA-3, T cell-specific factor-1, C\u03b2, and Id2; and show a surface marker pattern (CD44+CD25\u2212CD24+CD5\u2212) that is similar to the earliest T cell progenitors in the thymus. More mature committed intermediate progenitors in the marrow have rearranged the TCR gene loci, express V\u03b1 and V\u03b2 genes as well as CD3\u03b5, but do not express surface TCR or CD3 receptors. CTPs, but not progenitors from the thymus, reconstituted the \u03b1\u03b2 T cells in the lymphoid tissues of athymic nu\/nu mice. These reconstituted T cells vigorously secreted IFN-\u03b3 after stimulation in vitro, and protected the mice against lethal infection with murine CMV. In conclusion, CTPs in wild-type bone marrow can generate functional T cells via an extrathymic pathway in athymic nu\/nu mice.<\/jats:p>","DOI":"10.4049\/jimmunol.175.7.4363","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:01Z","timestamp":1398034501000},"page":"4363-4373","source":"Crossref","is-referenced-by-count":25,"title":["Stepwise Development of Committed Progenitors in the Bone Marrow That Generate Functional T Cells in the Absence of the Thymus"],"prefix":"10.1093","volume":"175","author":[{"given":"Marcos E","family":"Garci\u0301a-Ojeda","sequence":"first","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sussan","family":"Dejbakhsh-Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devavani","family":"Chatterjea-Matthes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"BitMansour","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving L","family":"Weissman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice M Y","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Strober","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2026020212142146600_R1","first-page":"14493","volume-title":"Proc. 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