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The continued expansion of the transferred T cells, even after stable T cell numbers have been reached, suggests that active cell death prevents further increase in T cell number. In this study, we show that wild-type T cells undergoing homeostatic proliferation are sensitive to Fas-mediated cell death. In the absence of Fas, T cells accumulate to significantly higher levels after transfer into lymphopenic recipients. Fas is, thus, a principal regulator of the expansion of peripheral T cells in response to self-peptide\/MHC during T cell homeostasis. As Fas-deficient lpr mice manifest no significant abnormalities in thymic negative selection or in foreign Ag-induced peripheral T cell deletion, their lymphadenopathy may result from unrestrained homeostatic proliferation.<\/jats:p>","DOI":"10.4049\/jimmunol.175.7.4374","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:01Z","timestamp":1398034501000},"page":"4374-4382","source":"Crossref","is-referenced-by-count":38,"title":["The Death Receptor Fas (CD95\/APO-1) Mediates the Deletion of T Lymphocytes Undergoing Homeostatic Proliferation"],"prefix":"10.1093","volume":"175","author":[{"given":"Karen A","family":"Fortner","sequence":"first","affiliation":[{"name":"Immunobiology Division, Department of Medicine, University of Vermont College of Medicine , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph C","family":"Budd","sequence":"additional","affiliation":[{"name":"Immunobiology Division, Department of Medicine, University of Vermont College of Medicine , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2026020212180327000_R1","first-page":"1127","volume-title":"J. 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