{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:46:01Z","timestamp":1793079961933,"version":"4.5.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite the recognized role of the T-bet transcription factor in the differentiation of Th1 cells, T-bet-deficient mice can develop small numbers of IFN-\u03b3-producing CD4 T cells. Although these are not sufficient to allow normal handling of some pathogens, T-bet-deficient mice do resolve infection with the intracellular pathogen Listeria monocytogenes. In contrast, we report that expression of T-bet is required for resistance to Salmonella infection. T-bet-deficient mice succumbed to infection with attenuated Salmonella and did not generate IFN-\u03b3-producing CD4 T cells or isotype-switched Salmonella-specific Ab responses. Spleen cells from Salmonella-infected T-bet-deficient mice secreted increased levels of IL-10, but not IL-4, upon in vitro restimulation. A Salmonella-specific TCR transgenic adoptive transfer system was used to further define the involvement of T-bet expression in the development of Salmonella-specific Th1 cells. Wild-type Salmonella-specific CD4 T cells activated in T-bet-deficient recipient mice displayed no defect in clonal expansion, contraction, or IFN-\u03b3 production. In contrast, T-bet-deficient, Salmonella-specific CD4 T cells activated in wild-type recipient mice produced less IFN-\u03b3 and more IL-2 upon in vivo restimulation. Therefore, expression of T-bet by CD4 T cells is required for the development of Salmonella-specific Th1 cells, regulation of IL-10 production, and resistance to Salmonella infection.<\/jats:p>","DOI":"10.4049\/jimmunol.175.7.4603","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:01Z","timestamp":1398034501000},"page":"4603-4610","source":"Crossref","is-referenced-by-count":136,"title":["Expression of T-bet by CD4 T Cells Is Essential for Resistance to\n                    <i>Salmonella<\/i>\n                    Infection"],"prefix":"10.1093","volume":"175","author":[{"given":"Rajesh","family":"Ravindran","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Immunology, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Foley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunology, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stoklasek","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunology, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H","family":"Glimcher","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Department of Medicine, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"McSorley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunology, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2026020212152681200_R1","first-page":"1335","volume-title":"Microbes Infect.","year":"2001"},{"key":"2026020212152681200_R2","first-page":"3321","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020212152681200_R3","first-page":"457","volume-title":"J. Leukocyte Biol.","year":"2000"},{"key":"2026020212152681200_R4","first-page":"132","volume-title":"Vet. J.","year":"2001"},{"key":"2026020212152681200_R5","first-page":"51","volume-title":"Curr. Opin. Microbiol.","year":"2004"},{"key":"2026020212152681200_R6","first-page":"3981","volume-title":"Infect. Immun.","year":"1993"},{"key":"2026020212152681200_R7","first-page":"46","volume-title":"Infect. Immun.","year":"2000"},{"key":"2026020212152681200_R8","first-page":"1648","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020212152681200_R9","first-page":"3344","volume-title":"Infect. Immun.","year":"2000"},{"key":"2026020212152681200_R10","first-page":"390","volume-title":"Microbiol. Rev.","year":"1989"},{"key":"2026020212152681200_R11","first-page":"6808","volume-title":"Infect. Immun.","year":"2003"},{"key":"2026020212152681200_R12","first-page":"4058","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212152681200_R13","first-page":"1026","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2026020212152681200_R14","first-page":"450","volume-title":"Curr. Opin. Immunol.","year":"2003"},{"key":"2026020212152681200_R15","first-page":"583","volume-title":"J. Interferon Cytokine Res.","year":"1997"},{"key":"2026020212152681200_R16","first-page":"655","volume-title":"Cell","year":"2000"},{"key":"2026020212152681200_R17","first-page":"338","volume-title":"Science","year":"2002"},{"key":"2026020212152681200_R18","first-page":"1566","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020212152681200_R19","first-page":"15818","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026020212152681200_R20","first-page":"7749","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026020212152681200_R21","first-page":"477","volume-title":"Immunity","year":"2004"},{"key":"2026020212152681200_R22","first-page":"79","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2026020212152681200_R23","first-page":"151","volume-title":"Annu. Rev. Immunol.","year":"1995"},{"key":"2026020212152681200_R24","first-page":"1153","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2026020212152681200_R25","first-page":"5918","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212152681200_R26","first-page":"336","volume-title":"Science","year":"2002"},{"key":"2026020212152681200_R27","first-page":"6884","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212152681200_R28","first-page":"29","volume-title":"J. Immunol. Methods","year":"1988"},{"key":"2026020212152681200_R29","first-page":"499","volume-title":"Immunol. Cell Biol.","year":"1999"},{"key":"2026020212152681200_R30","first-page":"986","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020212152681200_R31","first-page":"225","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020212152681200_R32","first-page":"888","volume-title":"Biotechnology","year":"1992"},{"key":"2026020212152681200_R33","first-page":"900","volume-title":"Nat. Rev. Immunol.","year":"2004"},{"key":"2026020212152681200_R34","first-page":"5545","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026020212152681200_R35","first-page":"4091","volume-title":"J. Immunol.","year":"2004"},{"key":"2026020212152681200_R36","first-page":"365","volume-title":"Immunity","year":"2002"},{"key":"2026020212152681200_R37","first-page":"4087","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020212152681200_R38","first-page":"1742","volume-title":"Science","year":"1993"},{"key":"2026020212152681200_R39","first-page":"109","volume-title":"Immunity","year":"1995"},{"key":"2026020212152681200_R40","first-page":"199","volume-title":"Infect. Immun.","year":"2002"},{"key":"2026020212152681200_R41","first-page":"6390","volume-title":"Infect. Immun.","year":"2004"},{"key":"2026020212152681200_R42","first-page":"291","volume-title":"J. Immunol.","year":"2003"},{"key":"2026020212152681200_R43","first-page":"45","volume-title":"Curr. Opin. Microbiol.","year":"2004"},{"key":"2026020212152681200_R44","first-page":"1041","volume-title":"Science","year":"2003"},{"key":"2026020212152681200_R45","first-page":"1907","volume-title":"Science","year":"2001"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/7\/4603\/62624084\/4603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/175\/7\/4603\/62624084\/4603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:18:58Z","timestamp":1770052738000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/175\/7\/4603\/8035981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,1]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2005,10,1]]},"published-print":{"date-parts":[[2005,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.175.7.4603","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,10]]},"published":{"date-parts":[[2005,10,1]]}}}