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We found that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR superfamily, signaling is involved in differentiation of long-lived CD8+ TCM cells following Listeria monocytogenes infection. Although CD8+ TEM cells transiently accumulated in the nonlymphoid tissues of CD30 ligand (CD153\u2212\/\u2212) mice after infection, long-lived memory CD8+ TCM cells were poorly generated in these mice. CCR7 mRNA expression was down-regulated in CD8+ T cells of the spleen of CD153\u2212\/\u2212 mice in vivo and the expression was up-regulated in CD8+ TEM cells by anti-CD30 mAb cross-linking in vitro. These results suggest that CD30\/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for TCM cells.<\/jats:p>","DOI":"10.4049\/jimmunol.175.7.4627","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:55:01Z","timestamp":1398034501000},"page":"4627-4634","source":"Crossref","is-referenced-by-count":43,"title":["A Novel Role of CD30\/CD30 Ligand Signaling in the Generation of Long-Lived Memory CD8+ T Cells"],"prefix":"10.1093","volume":"175","author":[{"given":"Hitoshi","family":"Nishimura","sequence":"first","affiliation":[{"name":"Division of Host Defense, Center for Prevention of Infectious Disease, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Yajima","sequence":"additional","affiliation":[{"name":"Division of Host Defense, Center for Prevention of Infectious Disease, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Muta","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard R","family":"Podack","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami , Miami, FL 33101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzaburo","family":"Tani","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Yoshikai","sequence":"additional","affiliation":[{"name":"Division of Host Defense, Center for Prevention of Infectious Disease, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"2026020212170083000_R1","first-page":"251","volume-title":"Nat. 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