{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:27:52Z","timestamp":1791350872970,"version":"4.3.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-12 and TNF-\u03b1 are central proinflammatory cytokines produced by macrophages and dendritic cells. Disregulation of TNF-\u03b1 is associated with sepsis and autoimmune diseases such as rheumatoid arthritis. However, new evidence suggests an anti-inflammatory role for TNF-\u03b1. TNF-\u03b1-treated murine macrophages produced less IL-12p70 and IL-23, after stimulation with IFN-\u03b3 and LPS. Frequency of IL-12p40-producing macrophages correspondingly decreased as measured by intracellular cytokine staining. IL-12p40 production was also inhibited in dendritic cells. TNFR1 was established as the main receptor involved in IL-12p40 regulation, because IL-12p40 levels were not affected by TNF-\u03b1 in TNFR1\u2212\/\u2212-derived macrophages. Macrophages activated during Listeria monocytogenes infection were more susceptible to inhibition by TNF-\u03b1 than cells from naive animals, which suggests a regulatory role for TNF-\u03b1 in later stages of infection. This nonapoptotic anti-inflammatory regulation of IL-12 and IL-23 is an important addition to the multitude of TNF-\u03b1-induced responses determined by cell-specific receptor signaling.<\/jats:p>","DOI":"10.4049\/jimmunol.175.8.5024","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:28:35Z","timestamp":1398032915000},"page":"5024-5033","source":"Crossref","is-referenced-by-count":119,"title":["Paradoxical Anti-Inflammatory Actions of TNF-\u03b1: Inhibition of IL-12 and IL-23 via TNF Receptor 1 in Macrophages and Dendritic Cells"],"prefix":"10.1093","volume":"175","author":[{"given":"Maria","family":"Zakharova","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Kirk","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,15]]},"reference":[{"key":"2026020212205047800_R1","first-page":"60","volume-title":"Am. 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