{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:34:31Z","timestamp":1791200071046,"version":"4.2.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In virus models explored in detail in mice, CTL typically focus on a few immunodominant determinants. In this study we use a multipronged approach to understand the diversity of CTL responses to vaccinia virus, a prototypic poxvirus with a genome \u223c20-fold larger than that of the model RNA viruses typically studied in mice. Based on predictive computational algorithms for peptide binding to HLA supertypes, we synthesized a panel of 2889 peptides to begin to create an immunomic map of human CTL responses to poxviruses. Using this panel in conjunction with CTLs from vaccinia virus-infected HLA transgenic mice, we identified 14 HLA-A*0201-, 4 HLA-A*1101-, and 3 HLA-B*0702-restricted CD8+ T cell determinants distributed over 20 distinct proteins. These peptides were capable of binding one or multiple A2, A3, and B7 supertype molecules with affinities typical of viral determinants. Surprisingly, many of the viral proteins recognized are predicted to be late gene products, in addition to the early intermediate gene products expected. Nearly all of the determinants identified have identical counterparts encoded by modified vaccinia virus Ankara as well as variola virus, the agent of smallpox. These findings have implications for the design of new smallpox vaccines and the understanding of immune responses to large DNA viruses in general.<\/jats:p>","DOI":"10.4049\/jimmunol.175.8.5504","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:28:35Z","timestamp":1398032915000},"page":"5504-5515","source":"Crossref","is-referenced-by-count":80,"title":["HLA-A*0201, HLA-A*1101, and HLA-B*0702 Transgenic Mice Recognize Numerous Poxvirus Determinants from a Wide Variety of Viral Gene Products"],"prefix":"10.1093","volume":"175","author":[{"given":"Valerie","family":"Pasquetto","sequence":"first","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh-Hoa","family":"Bui","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rielle","family":"Giannino","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fareed","family":"Mirza","sequence":"additional","affiliation":[{"name":"Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University , Oxford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sidney","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Oseroff","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Tscharke","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"Division of Immunology and Infectious Diseases, Queensland Institute of Medical Research , Herston, Queensland ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Irvine","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack R","family":"Bennink","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Southwood","sequence":"additional","affiliation":[{"name":"Epimmune Incorporated , San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cerundolo","sequence":"additional","affiliation":[{"name":"Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University , Oxford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Grey","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W","family":"Yewdell","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology , San Diego, CA 92109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,15]]},"reference":[{"key":"2026020212135719000_R1","first-page":"738","volume-title":"J. 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