{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:35:34Z","timestamp":1776263734582,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD8 T cell populations restricted by H2-M3 MHC class Ib molecules expand rapidly during primary Listeria monocytogenes infection but only minimally upon reinfection. In contrast, CD8 T cells restricted by MHC class Ia molecules undergo more delayed expansion during primary infection but rapid and robust expansion following reinfection. In this study we demonstrate that primary H2-M3-restricted CD8 T cell responses are unaffected by the frequency of naive MHC class Ia-restricted T cells during L. monocytogenes infection. The magnitude of H2-M3-restricted memory responses, in contrast, is down-modulated by increasing frequencies of MHC class Ia-restricted effector T cells following secondary systemic infection. Suppression by MHC class Ia-restricted T cells, however, is not a universal feature of MHC class Ib-restricted memory responses. Primary systemic L. monocytogenes infection followed by secondary tissue infection, for example, results in robust expansion of H2-M3-restricted memory T cells in draining lymph nodes, despite the activation of MHC class Ia-restricted memory T cell responses. Thus, whereas MHC class Ia-restricted memory T cell populations predominate in spleens following systemic reinfection, H2-M3-restricted memory T cell responses remain prominent in lymph nodes draining localized infections. Our studies demonstrate that interactions between CD8 T cell populations can differ, depending on the status of the responding T cells (naive vs memory) and the route of reinfection. These results may have important implications for prime-boost vaccination strategies.<\/jats:p>","DOI":"10.4049\/jimmunol.175.9.5998","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T02:54:18Z","timestamp":1398048858000},"page":"5998-6005","source":"Crossref","is-referenced-by-count":4,"title":["Distinct Regulation of H2-M3-Restricted Memory T Cell Responses in Lymph Node and Spleen"],"prefix":"10.1093","volume":"175","author":[{"given":"Alexander","family":"Ploss","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"},{"name":"Weill Graduate School of Medical Sciences of Cornell University, Immunology Program , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Leiner","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric G","family":"Pamer","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"2025032705541263700_R1","first-page":"29","volume-title":"Annu. 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