{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:18:56Z","timestamp":1770099536985,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteopontin (OPN) has been defined as a key cytokine promoting the release of IL-12 and hence inducing the development of protective cell-mediated immunity to viruses and intracellular pathogens. To further characterize the role of OPN in antiviral immunity, OPN-deficient (OPN\u2212\/\u2212) mice were analyzed after infection with influenza virus and vaccinia virus. Surprisingly, we found that viral clearance, lung inflammation, and recruitment of effector T cells to the lung were unaffected in OPN\u2212\/\u2212 mice after influenza infection. Furthermore, effector status of T cells was normal as demonstrated by normal IFN-\u03b3 production and CTL lytic activity. Moreover, activation and Th1 differentiation of naive TCR transgenic CD4+ T cells by dendritic cells and cognate Ag was normal in the absence of OPN in vitro. Contrary to a previous report, we found that OPN\u2212\/\u2212 mice mounted a normal immune response to Listeria monocytogenes. In conclusion, OPN is dispensable for antiviral immune responses against influenza virus and vaccinia virus.<\/jats:p>","DOI":"10.4049\/jimmunol.175.9.6006","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:54:18Z","timestamp":1398034458000},"page":"6006-6013","source":"Crossref","is-referenced-by-count":29,"title":["Osteopontin Is Not Required for the Development of Th1 Responses and Viral Immunity"],"prefix":"10.1093","volume":"175","author":[{"given":"Brian","family":"Abel","sequence":"first","affiliation":[{"name":"Molecular Biomedicine, Swiss Federal Institute of Technology ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Freigang","sequence":"additional","affiliation":[{"name":"Institute for Experimental Immunology , Zurich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin F","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Cytos Biotechnology AG , Zurich-Schlieren ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Boschert","sequence":"additional","affiliation":[{"name":"Department of Immunology, Serono Pharmaceutical Research Institute , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kopf","sequence":"additional","affiliation":[{"name":"Molecular Biomedicine, Swiss Federal Institute of Technology ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"2026020212142619300_R1","first-page":"860","volume-title":"Science","year":"2000"},{"key":"2026020212142619300_R2","first-page":"4223","volume-title":"Infect. 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