{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:04:55Z","timestamp":1791302695653,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dendritic cells (DC) are potent inducers of immune responses. DC have been shown to infiltrate tumors, but very little is known about the functional status of these naturally occurring tumor-infiltrating DC (TIDC). In this study, the status and function of TIDC from several types of mouse melanoma were investigated in detail. CD11c+\/MHC II+ cells, consistent with a DC phenotype, were found in all of transplantable or spontaneous melanomas studied. These TIDC were predominantly myeloid (CD11c+\/CD8\u03b1\u2212\/B220\u2212) in nature with small numbers of plasmacytoid (CD11c+\/B220+). TIDC had an intermediate maturation phenotype with some expression of costimulatory molecules and the capacity to take up particles. Upon culture overnight ex vivo, the TIDC markedly up-regulated the expression of costimulatory molecules and also increased IL-12 production. Importantly, such ex vivo-matured TIDC pulsed with OVA were able to migrate to lymph nodes, to activate naive OVA-specific CD4+ and CD8+ T cells, and to confer protection against a challenge with OVA-expressing tumor cells. In conclusion, melanomas are infiltrated by functional DC that can act as fully competent APC. These APC have the potential to be manipulated and may therefore represent a promising target for cancer immunotherapy.<\/jats:p>","DOI":"10.4049\/jimmunol.176.1.61","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T09:37:11Z","timestamp":1398245831000},"page":"61-67","source":"Crossref","is-referenced-by-count":77,"title":["Tumor-Infiltrating Dendritic Cells Are Potent Antigen-Presenting Cells Able to Activate T Cells and Mediate Tumor Rejection"],"prefix":"10.1093","volume":"176","author":[{"given":"Olivier","family":"Preynat-Seauve","sequence":"first","affiliation":[{"name":"Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center , Geneva ,","place":["Switzerland"]},{"name":"Department of Dermatology, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prisca","family":"Schuler","sequence":"additional","affiliation":[{"name":"Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center , Geneva ,","place":["Switzerland"]},{"name":"Department of Dermatology, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Contassot","sequence":"additional","affiliation":[{"name":"Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center , Geneva ,","place":["Switzerland"]},{"name":"Department of Dermatology, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Beermann","sequence":"additional","affiliation":[{"name":"Institut Suisse de Recherches Experimentales sur le Cancer, Swiss Institute for Experimental Cancer Research , Epalinges ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Huard","sequence":"additional","affiliation":[{"name":"Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center , Geneva ,","place":["Switzerland"]},{"name":"Department of Dermatology, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E","family":"French","sequence":"additional","affiliation":[{"name":"Louis Jeantet Skin Cancer Laboratory, Department of Pathology and Immunology, Geneva University Medical Center , Geneva ,","place":["Switzerland"]},{"name":"Department of Dermatology, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,1,1]]},"reference":[{"key":"2026020211355998600_R1","first-page":"245","volume-title":"Nature","year":"1998"},{"key":"2026020211355998600_R2","first-page":"33","volume-title":"Semin. 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