{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:16:42Z","timestamp":1791256602311,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ectopic formation of secondary lymphoid tissue is initiated by the local attraction of naive T and B cells. In this study, we describe a novel type of organized lymphoid structure in the lung of human idiopathic pulmonary fibrosis, with key features of lymphoid neogenesis, including: 1) recently activated CD40 ligand (CD40L)+ T cells; 2) variable numbers of activated CD40+\/CD40L+ B cells, sometimes organized in follicles; 3) fully mature dendritic cells (DC) expressing CD40, CD83, CD86, and DC-lysosome-associated membrane protein; 4) the expression of the chemokine CCL21; 5) the presence of vessels with characteristics of high endothelial venules; and 6) a dense network of follicular DC. Surprisingly, these structures are devoid of CCR7+ naive T cells, proliferating lymphocytes, and germinal centers, suggesting that newly recruited activated DC and Ag-experienced lymphocytes can drive lymphoid neogenesis and that factors present within the lymphoid aggregates, such as CD40L, are essential to induce DC maturation.<\/jats:p>","DOI":"10.4049\/jimmunol.176.10.5735","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:29:28Z","timestamp":1398025768000},"page":"5735-5739","source":"Crossref","is-referenced-by-count":163,"title":["Cutting Edge: Nonproliferating Mature Immune Cells Form a Novel Type of Organized Lymphoid Structure in Idiopathic Pulmonary Fibrosis"],"prefix":"10.1093","volume":"176","author":[{"given":"Joe\u0308lle","family":"Marchal-Somme\u0301","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 700; Universite\u0301 Paris 7, Faculte\u0301 de Me\u0301decine Xavier Bichat , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurdagul","family":"Uzunhan","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 700; Universite\u0301 Paris 7, Faculte\u0301 de Me\u0301decine Xavier Bichat , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Marchand-Adam","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 700; Universite\u0301 Paris 7, Faculte\u0301 de Me\u0301decine Xavier Bichat , Paris ,","place":["France"]},{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Service de Pneumologie, Ho\u0302pital Bichat , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valeyre","sequence":"additional","affiliation":[{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Service de Pneumologie, Ho\u0302pital Avicenne , Bobigny ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassili","family":"Soumelis","sequence":"additional","affiliation":[{"name":"Institut Curie, Laboratoire d\u2019Immunologie Clinique , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 700; Universite\u0301 Paris 7, Faculte\u0301 de Me\u0301decine Xavier Bichat , Paris ,","place":["France"]},{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Service de Pneumologie, Ho\u0302pital Bichat , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Soler","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 700; Universite\u0301 Paris 7, Faculte\u0301 de Me\u0301decine Xavier Bichat , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"2026020211401929900_R1","first-page":"331","volume-title":"J. 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