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In this study, we show that both chains of the IL-27 receptor complex, IL-27R and gp130, are constitutively expressed at the surface of naive and memory human tonsillar B cells, and are induced on germinal center B cells following CD40 stimulation. In naive B cells, IL-27 induced strong STAT1 and STAT3 phosphorylation, whereas it induced moderate STAT1 and low STAT3 activation in memory B cells. IL-27 induced T-bet expression in naive and memory B cells stimulated by CD40 or surface Ig engagement, but induced significant IL-12R\u03b22 surface expression in anti-Ig-stimulated naive B cells only. In anti-Ig-stimulated naive or memory B cells, IL-27 also induced CD54, CD86, and CD95 surface expression. In addition, IL-27 increased proliferation of anti-Ig-activated naive B cells and of anti-CD40-activated naive and germinal center B cells, but not of CD40-activated memory B cells. These data indicate that the B cell response to IL-27 is modulated during B cell differentiation and varies depending on the mode of B cell activation.<\/jats:p>","DOI":"10.4049\/jimmunol.176.10.5890","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:29:28Z","timestamp":1398025768000},"page":"5890-5897","source":"Crossref","is-referenced-by-count":94,"title":["Differential Effects of IL-27 on Human B Cell Subsets"],"prefix":"10.1093","volume":"176","author":[{"given":"Fre\u0301de\u0301rique","family":"Larousserie","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Institut Fe\u0301de\u0301ratif de Recherche Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascaline","family":"Charlot","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Institut Fe\u0301de\u0301ratif de Recherche Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Bardel","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Institut Fe\u0301de\u0301ratif de Recherche Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josy","family":"Froger","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 564 , Angers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Kastelein","sequence":"additional","affiliation":[{"name":"Schering-Plough Biopharma (formerly DNAX) , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Devergne","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Institut Fe\u0301de\u0301ratif de Recherche Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"2026020211400850900_R1","first-page":"1143","volume-title":"J. 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