{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:30:38Z","timestamp":1773246638331,"version":"3.50.1"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The proinflammatory T cell cytokine IL-17 is a potent inducer of other cytokines such as IL-1 and TNF-\u03b1. The contribution of TNF in IL-17-induced joint inflammation is unclear. In this work we demonstrate using TNF-\u03b1-deficient mice that TNF-\u03b1 is required in IL-17-induced joint pathology under naive conditions in vivo. However, overexpression of IL-17 aggravated K\/B\u00d7N serum transfer arthritis to a similar degree in TNF-\u03b1-deficient mice and their wild-type counterparts, indicating that the TNF dependency of IL-17-induced pathology is lost under arthritic conditions. Also, during the course of the streptococcal cell wall-induced arthritis model, IL-17 was able to enhance inflammation and cartilage damage in the absence of TNF. Additional blocking of IL-1 during IL-17-enhanced streptococcal cell wall-induced arthritis did not reduce joint pathology in TNF-deficient mice, indicating that IL-1 is not responsible for this loss of TNF dependency. These data provide further understanding of the cytokine interplay during inflammation and demonstrate that, despite a strong TNF dependency under naive conditions, IL-17 acts independently of TNF under arthritic conditions.<\/jats:p>","DOI":"10.4049\/jimmunol.176.10.6262","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:29:28Z","timestamp":1398040168000},"page":"6262-6269","source":"Crossref","is-referenced-by-count":101,"title":["Interleukin-17 Acts Independently of TNF-\u03b1 under Arthritic Conditions"],"prefix":"10.1093","volume":"176","author":[{"given":"Marije I","family":"Koenders","sequence":"first","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Lubberts","sequence":"additional","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fons A J","family":"van de Loo","sequence":"additional","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Oppers-Walgreen","sequence":"additional","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liduine","family":"van den Bersselaar","sequence":"additional","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique M","family":"Helsen","sequence":"additional","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco E","family":"Di Padova","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, Department of Pediatric and Pulmonology , Pittsburgh, PA 15213"},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo A B","family":"Joosten","sequence":"additional","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim B","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center , Nijmegen ,","place":["the Netherlands"]},{"name":"Novartis Institutes for Biomedical Research , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"2025032614523560700_R1","first-page":"1293","volume-title":"Arthritis Rheum.","year":"2001"},{"key":"2025032614523560700_R2","first-page":"730","volume-title":"Ann. 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