{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:23:22Z","timestamp":1784759002349,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Immunoproteasome subunits low-molecular mass polypeptide (LMP)2 and LMP7 affect Ag presentation by MHC class I molecules. In the present study, we investigated the function of the third immunosubunit LMP10\/multicatalytic endopeptidase complex-like (MECL)-1 (\u03b22i) in MECL-1 gene-targeted mice. The number of CD8+ splenocytes in MECL-1\u2212\/\u2212 mice was 20% lower than in wild-type mice. Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276\u2013286\/Db and NP205\u2013212\/Kb in MECL-1\u2212\/\u2212 mice. The weak CTL response to GP276\u2013286\/Db was not due to an impaired generation of this epitope but was attributed to a decreased precursor frequency of GP276\u2013286\/Db-specific T cells. The expansion of TCR-V\u03b210+ T cells, which contain GP276\u2013286\/Db-specific cells, was reduced in LCMV-infected MECL-1\u2212\/\u2212 mice. Taken together, our data reveal an in vivo function of MECL-1 in codetermining the T cell repertoire for an antiviral CTL response.<\/jats:p>","DOI":"10.4049\/jimmunol.176.11.6665","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:47:30Z","timestamp":1398037650000},"page":"6665-6672","source":"Crossref","is-referenced-by-count":99,"title":["An Altered T Cell Repertoire in MECL-1-Deficient Mice"],"prefix":"10.1093","volume":"176","author":[{"given":"Michael","family":"Basler","sequence":"first","affiliation":[{"name":"Division of Immunology, Department of Biology, University of Constance , Konstanz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Moebius","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Biology, University of Constance , Konstanz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Elenich","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Groettrup","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Biology, University of Constance , Konstanz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Monaco","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"2025032615121264500_R1","first-page":"429","volume-title":"Immunol. 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